Bi-terminal pegylated integrin-binding peptides and methods of use thereof
Abstract
The present invention provides bi-terminal PEGylated peptide conjugates that target an integrin such as αvβ6 integrin. In particular embodiments, the peptide conjugates of the present invention further comprise a biological agent such as an imaging agent or a therapeutic agent, e.g., covalently attached to one of the PEG moieties. The peptide conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue and for treating integrin-mediated diseases and disorders such as cancer, inflammatory diseases, autoimmune diseases, chronic fibrosis, chronic obstructive pulmonary disease (COPD), lung emphysema, and chronic wounding skin disease. Compositions and kits containing the peptide conjugates of the present invention find utility in a wide range of applications including, e.g., in vivo imaging and immunotherapy.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of California, Davis, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1805506
- Patent Number(s):
- 10919932
- Application Number:
- 15/292,564
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- SC0002061
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 10/13/2016
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Hausner, Sven H., and Sutcliffe, Julie L. Bi-terminal pegylated integrin-binding peptides and methods of use thereof. United States: N. p., 2021.
Web.
Hausner, Sven H., & Sutcliffe, Julie L. Bi-terminal pegylated integrin-binding peptides and methods of use thereof. United States.
Hausner, Sven H., and Sutcliffe, Julie L. Tue .
"Bi-terminal pegylated integrin-binding peptides and methods of use thereof". United States. https://www.osti.gov/servlets/purl/1805506.
@article{osti_1805506,
title = {Bi-terminal pegylated integrin-binding peptides and methods of use thereof},
author = {Hausner, Sven H. and Sutcliffe, Julie L.},
abstractNote = {The present invention provides bi-terminal PEGylated peptide conjugates that target an integrin such as αvβ6 integrin. In particular embodiments, the peptide conjugates of the present invention further comprise a biological agent such as an imaging agent or a therapeutic agent, e.g., covalently attached to one of the PEG moieties. The peptide conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue and for treating integrin-mediated diseases and disorders such as cancer, inflammatory diseases, autoimmune diseases, chronic fibrosis, chronic obstructive pulmonary disease (COPD), lung emphysema, and chronic wounding skin disease. Compositions and kits containing the peptide conjugates of the present invention find utility in a wide range of applications including, e.g., in vivo imaging and immunotherapy.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2021},
month = {2}
}
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- US Patent Application 13/988252; 20130315996
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- Mezo, Adam R.; McDonnell, Kevin
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