skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof

Patent ·
OSTI ID:1650986
; ; ;

Among the various aspects of the present disclosure is the provision of a compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof. Provided are imaging agents for imaging S1P1 and S1P1 associated diseases, disorders, and conditions. Also provided are therapeutic compositions and methods for the treatment of S1P1 associated diseases, disorders, and conditions.

Research Organization:
Washington Univ., St. Louis, MO (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
SC0008432
Assignee:
Washington University (St. Louis, MO)
Patent Number(s):
10,676,467
Application Number:
16/025,324
OSTI ID:
1650986
Resource Relation:
Patent File Date: 07/02/2018
Country of Publication:
United States
Language:
English

References (5)

Composition and Methods for Treating Female Sexual Dysfunction patent-application January 2002
Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof patent May 2006
Oxadiazoles, processes for their preparation and their use as medicaments patent August 2001
Method of Combating Nematodes patent June 1965
Substituted 3-ARYL-5-ARYL-[1,2,4]-Oxadiazoles and Analogs as Activators of Caspases and Inducers of Apoptosis and the Use Thereof patent-application March 2003

Similar Records

Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-{kappa}B ligand (RANKL) expression in rheumatoid arthritis
Journal Article · Fri Mar 09 00:00:00 EST 2012 · Biochemical and Biophysical Research Communications · OSTI ID:1650986
+8 more
A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression
Journal Article · Tue Jun 09 00:00:00 EDT 2015 · Organic and Biomolecular Chemistry · OSTI ID:1650986
+3 more
Design, Synthesis, and In Vitro and In Vivo Evaluation of an 18 F-Labeled Sphingosine 1-Phosphate Receptor 1 (S1P1) PET Tracer
Journal Article · Thu Jun 09 00:00:00 EDT 2016 · Journal of Medicinal Chemistry · OSTI ID:1650986
+4 more

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES