Bi-terminal pegylated integrin-binding peptides and methods of use thereof

Hausner, Sven H.; Sutcliffe, Julie L.

Title: Bi-terminal pegylated integrin-binding peptides and methods of use thereof

Patent · Tue Nov 01 00:00:00 EDT 2022

OSTI ID:1986773

Hausner, Sven H.; Sutcliffe, Julie L.

The present invention provides bi-terminal PEGylated peptide conjugates that target an integrin such as αvβ6 integrin. In particular embodiments, the peptide conjugates of the present invention further comprise a biological agent such as an imaging agent or a therapeutic agent, e.g., covalently attached to one of the PEG moieties. The peptide conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue and for treating integrin-mediated diseases and disorders such as cancer, inflammatory diseases, autoimmune diseases, chronic fibrosis, chronic obstructive pulmonary disease (COPD), lung emphysema, and chronic wounding skin disease. Compositions and kits containing the peptide conjugates of the present invention find utility in a wide range of applications including, e.g., in vivo imaging and immunotherapy.

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Research Organization:: Univ. of California, Davis, CA (United States)

Sponsoring Organization:: USDOE; National Institutes of Health (NIH)

DOE Contract Number:: SC0002061; 1RC4EB012836-01

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 11,485,758

Application Number:: 17/131,324

OSTI ID:: 1986773

Resource Relation:: Patent File Date: 12/22/2020

Country of Publication:: United States

Language:: English

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