Title: Prostate cancer-associated secreted proteins

Abstract

Methods are provided for treating a subject with prostate cancer and/or diagnosing a subject at risk for prostate cancer, which can include measuring increased expression of at least two prostate cancer-related molecules in a sample obtained from a subject, including the prostate cancer-related molecules AGR2, AGR3, CRISP3, CCL3, CEACAM5, CEACAM6, IL24, MMP9, CXCL14, CD90, POSTN, and SFRP4. The methods can include administering at therapy to a subject with prostate cancer. Methods are provided for treating a subject with intermediate- or high-risk prostate cancer, which can include measuring increased expression of MMP9 in a sample obtained from a subject compared to a control representing expression of MMP9 expected in a sample from a subject who has low-risk prostate cancer.

Inventors:

Qian, Wei-Jun; Shi, Tujin; Liu, Alvin Y.

Issue Date:

Tue Jul 28 00:00:00 EDT 2020

Research Org.:

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1735077

Patent Number(s):

10725053

Application Number:

15/839,635

Assignee:

Battelle Memorial Institute (Richland, WA); University of Washington (Seattle, WA)

Patent Classifications (CPCs):

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES

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C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C12Q1/37 - involving peptidase or proteinase
C12Q1/533 - involving isomerase

C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES

C12Y304/24035 - Gelatinase B
C12Y503/04001 - Protein disulfide-isomerase

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N2333/47 - Assays involving proteins of known structure or function as defined in the subgroups
G01N2333/52 - Assays involving cytokines
G01N2333/54 - Interleukins [IL]
G01N2333/70503 - Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
G01N2333/70596 - Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
G01N2333/96486 - Metalloendopeptidases
G01N2333/99 - Isomerases
G01N33/57434 - {of prostate}
G01N33/6848 - {Methods of protein analysis involving mass spectrometry}
G01N33/6863 - {Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors}
G01N33/6869 - {Interleukin}
G01N33/6893 - {related to diseases not provided for elsewhere}

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DOE Contract Number:  

AC05-76RL01830

Resource Type:

Patent

Resource Relation:

Patent File Date: 12/12/2017

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES