DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Artificial secretion peptides for heterologous protein production

Abstract

Provided herein, in some embodiments, are artificial secretion peptides capable of directing secretion from Lactobacillus for use, for example, in producing heterologous proteins, including therapeutic proteins.

Inventors:
;
Issue Date:
Research Org.:
Harvard Univ., Cambridge, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1986941
Patent Number(s):
11530433
Application Number:
16/757,687
Assignee:
President and Fellows of Harvard College (Cambridge, MA)
DOE Contract Number:  
FG02-02ER63445
Resource Type:
Patent
Resource Relation:
Patent File Date: 10/19/2018
Country of Publication:
United States
Language:
English

Citation Formats

Debnath, Anik, and Church, George. Artificial secretion peptides for heterologous protein production. United States: N. p., 2022. Web.
Debnath, Anik, & Church, George. Artificial secretion peptides for heterologous protein production. United States.
Debnath, Anik, and Church, George. Tue . "Artificial secretion peptides for heterologous protein production". United States. https://www.osti.gov/servlets/purl/1986941.
@article{osti_1986941,
title = {Artificial secretion peptides for heterologous protein production},
author = {Debnath, Anik and Church, George},
abstractNote = {Provided herein, in some embodiments, are artificial secretion peptides capable of directing secretion from Lactobacillus for use, for example, in producing heterologous proteins, including therapeutic proteins.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Dec 20 00:00:00 EST 2022},
month = {Tue Dec 20 00:00:00 EST 2022}
}

Works referenced in this record:

Female Reproductive Tract And Anal Prophylaxes
patent-application, May 2011


Expression of antibody or a fragment thereof in lactobacillus
patent, October 2014


Genome-wide analysis of signal peptide functionality in Lactobacillus plantarum WCFS1
journal, January 2009


Lactobacilli expressing biologically active polypeptides and uses thereof
patent, February 2007


Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis
journal, January 2010


Polypeptides Comprising Unnatural Amino Acids, Methods for Their Production and Uses Therefor
patent-application, February 2008


Author Correction: Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents
journal, February 2020


Food Products Comprising Probiotic Micro-Organisms And Antibodies
patent-application, September 2009


Artificial Bioluminescent Enzyme
patent-application, October 2015


Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human  -defensin 3
journal, July 2003


Vaginal lactobacillus medicant
patent, April 2002


Exopolysaccharides of Lactobacillus rhamnosus GG form a protective shield against innate immune factors in the intestine
journal, August 2010


Expression of Human Immunodeficiency Virus Type 1 Neutralizing Antibody Fragments Using Human VaginalLactobacillus
journal, November 2016


Rapid Conformational Epitope Mapping of Anti-gp120 Antibodies with a Designed Mutant Panel Displayed on Yeast
journal, January 2013


Treatment of HIV and AIDS using probiotic lactobacillus reuteri
patent-application, June 2010


Heterologous protein secretion byLactobacillus plantarumusing homologous signal peptides
journal, July 2008


Protease-Activatable Pore-Forming Polypeptides
patent-application, May 2013


Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization
journal, May 2012