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Title: Use of galerina marginata genes and proteins for peptide production

Abstract

The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptides and cyclic peptide production in mushrooms. In particular, the present invention relates to using genes and proteins from Galerina species encoding peptides specifically relating to amatoxins in addition to proteins involved with processing cyclic peptide toxins. In a preferred embodiment, the present invention also relates to methods for making small peptides and small cyclic peptides including peptides similar to amanitin. Further, the present inventions relate to providing kits for making small peptides.

Inventors:
; ; ;
Issue Date:
Research Org.:
Michigan State Univ., East Lansing, MI (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1433343
Patent Number(s):
9932571
Application Number:
15/437,359
Assignee:
Board of Trustees of Michigan State University (East Lansing, MI)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
FG02-91ER20021
Resource Type:
Patent
Resource Relation:
Patent File Date: 2017 Feb 20
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Hallen-Adams, Heather E., Scott-Craig, John S., Walton, Jonathan D., and Luo, Hong. Use of galerina marginata genes and proteins for peptide production. United States: N. p., 2018. Web.
Hallen-Adams, Heather E., Scott-Craig, John S., Walton, Jonathan D., & Luo, Hong. Use of galerina marginata genes and proteins for peptide production. United States.
Hallen-Adams, Heather E., Scott-Craig, John S., Walton, Jonathan D., and Luo, Hong. Tue . "Use of galerina marginata genes and proteins for peptide production". United States. https://www.osti.gov/servlets/purl/1433343.
@article{osti_1433343,
title = {Use of galerina marginata genes and proteins for peptide production},
author = {Hallen-Adams, Heather E. and Scott-Craig, John S. and Walton, Jonathan D. and Luo, Hong},
abstractNote = {The present invention relates to compositions and methods comprising genes and peptides associated with cyclic peptides and cyclic peptide production in mushrooms. In particular, the present invention relates to using genes and proteins from Galerina species encoding peptides specifically relating to amatoxins in addition to proteins involved with processing cyclic peptide toxins. In a preferred embodiment, the present invention also relates to methods for making small peptides and small cyclic peptides including peptides similar to amanitin. Further, the present inventions relate to providing kits for making small peptides.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2018},
month = {4}
}

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