skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Artificial secretion peptides for heterologous protein production

Patent ·
OSTI ID:1986941

Provided herein, in some embodiments, are artificial secretion peptides capable of directing secretion from Lactobacillus for use, for example, in producing heterologous proteins, including therapeutic proteins.

Research Organization:
Harvard Univ., Cambridge, MA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-02ER63445
Assignee:
President and Fellows of Harvard College (Cambridge, MA)
Patent Number(s):
11,530,433
Application Number:
16/757,687
OSTI ID:
1986941
Resource Relation:
Patent File Date: 10/19/2018
Country of Publication:
United States
Language:
English

References (23)

Female Reproductive Tract And Anal Prophylaxes patent-application May 2011
Expression of antibody or a fragment thereof in lactobacillus patent October 2014
Genome-wide analysis of signal peptide functionality in Lactobacillus plantarum WCFS1 journal January 2009
Lactobacilli expressing biologically active polypeptides and uses thereof patent February 2007
Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10 journal August 2000
Determination of intrinsic hydrophilicity/hydrophobicity of amino acid side chains in peptides in the absence of nearest-neighbor or conformational effects journal January 2006
Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis journal January 2010
Protection from viral infection via colonization of mucosal membranes with genetically modified bacteria patent March 1998
Polypeptides Comprising Unnatural Amino Acids, Methods for Their Production and Uses Therefor patent-application February 2008
Author Correction: Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents journal February 2020
Food Products Comprising Probiotic Micro-Organisms And Antibodies patent-application September 2009
Artificial Bioluminescent Enzyme patent-application October 2015
Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human  -defensin 3 journal July 2003
Vaginal lactobacillus medicant patent April 2002
TM Finder: A prediction program for transmembrane protein segments using a combination of hydrophobicity and nonpolar phase helicity scales journal January 2001
Exopolysaccharides of Lactobacillus rhamnosus GG form a protective shield against innate immune factors in the intestine journal August 2010
Expression of Human Immunodeficiency Virus Type 1 Neutralizing Antibody Fragments Using Human VaginalLactobacillus journal November 2016
Rapid Conformational Epitope Mapping of Anti-gp120 Antibodies with a Designed Mutant Panel Displayed on Yeast journal January 2013
Treatment of HIV and AIDS using probiotic lactobacillus reuteri patent-application June 2010
Heterologous protein secretion byLactobacillus plantarumusing homologous signal peptides journal July 2008
Straightforward Selection of Broadly Neutralizing Single-Domain Antibodies Targeting the Conserved CD4 and Coreceptor Binding Sites of HIV-1 gp120 journal November 2012
Protease-Activatable Pore-Forming Polypeptides patent-application May 2013
Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization journal May 2012