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Title: Method for detecting the presence of prostate cancer

Abstract

The present invention relates to compositions and methods for cancer diagnosis, treatment and drug screening. In particular, the present invention provides compositions and methods for targeting the nuclear translocation of IkB kinase-.alpha. (IKK.alpha.) and the IKK.alpha.-mediated suppression of Maspin expression observed in metastatic prostate cancer cells.

Inventors:
; ;
Issue Date:
Research Org.:
Univ. of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1176232
Patent Number(s):
7695921
Application Number:
12/004,696
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
FG03-86ER60429
Resource Type:
Patent
Resource Relation:
Patent File Date: 2007 Dec 21
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats

Karin, Michael, Luo, Jun-Li, and Tan, Wei. Method for detecting the presence of prostate cancer. United States: N. p., 2010. Web.
Karin, Michael, Luo, Jun-Li, & Tan, Wei. Method for detecting the presence of prostate cancer. United States.
Karin, Michael, Luo, Jun-Li, and Tan, Wei. Tue . "Method for detecting the presence of prostate cancer". United States. https://www.osti.gov/servlets/purl/1176232.
@article{osti_1176232,
title = {Method for detecting the presence of prostate cancer},
author = {Karin, Michael and Luo, Jun-Li and Tan, Wei},
abstractNote = {The present invention relates to compositions and methods for cancer diagnosis, treatment and drug screening. In particular, the present invention provides compositions and methods for targeting the nuclear translocation of IkB kinase-.alpha. (IKK.alpha.) and the IKK.alpha.-mediated suppression of Maspin expression observed in metastatic prostate cancer cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {4}
}

Works referenced in this record:

Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin
journal, March 2007


IκB kinase-α acts in the epidermis to control skeletal and craniofacial morphogenesis
journal, April 2004


Maspin is up-regulated in premalignant prostate epithelia
journal, November 2002