Method for detecting the presence of prostate cancer

Karin, Michael; Luo, Jun-Li; Tan, Wei

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Title: Method for detecting the presence of prostate cancer

Abstract

The present invention relates to compositions and methods for cancer diagnosis, treatment and drug screening. In particular, the present invention provides compositions and methods for targeting the nuclear translocation of IkB kinase-.alpha. (IKK.alpha.) and the IKK.alpha.-mediated suppression of Maspin expression observed in metastatic prostate cancer cells.

Inventors:: Karin, Michael; Luo, Jun-Li; Tan, Wei

Issue Date:: Tue Apr 13 00:00:00 EDT 2010

Research Org.:: Univ. of California, Oakland, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1176232

Patent Number(s):: 7695921

Application Number:: 12/004,696

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N2333/91215 - with a definite EC number
G01N2500/10 - involving cells
G01N33/574 - for cancer

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DOE Contract Number:: FG03-86ER60429

Resource Type:: Patent

Resource Relation:: Patent File Date: 2007 Dec 21

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats


                    Karin, Michael, Luo, Jun-Li, and Tan, Wei. Method for detecting the presence of prostate cancer.  United States: N. p., 2010. 
        Web.

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                    Karin, Michael, Luo, Jun-Li, & Tan, Wei. Method for detecting the presence of prostate cancer.  United States.

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                    Karin, Michael, Luo, Jun-Li, and Tan, Wei. Tue .  
        "Method for detecting the presence of prostate cancer".  United States.  https://www.osti.gov/servlets/purl/1176232.

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@article{osti_1176232,

  title        = {Method for detecting the presence of prostate cancer},

  author       = {Karin, Michael and Luo, Jun-Li and Tan, Wei},

  abstractNote = {The present invention relates to compositions and methods for cancer diagnosis, treatment and drug screening. In particular, the present invention provides compositions and methods for targeting the nuclear translocation of IkB kinase-.alpha. (IKK.alpha.) and the IKK.alpha.-mediated suppression of Maspin expression observed in metastatic prostate cancer cells.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Apr 13 00:00:00 EDT 2010},

  month        = {Tue Apr 13 00:00:00 EDT 2010}

}

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Works referenced in this record:

Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin
journal, March 2007

Luo, Jun-Li; Tan, Wei; Ricono, Jill M.
Nature, Vol. 446, Issue 7136
https://doi.org/10.1038/nature05656

IκB kinase-α acts in the epidermis to control skeletal and craniofacial morphogenesis
journal, April 2004

Sil, Alok K.; Maeda, Shin; Sano, Yuji
Nature, Vol. 428, Issue 6983
https://doi.org/10.1038/nature02421

Maspin is up-regulated in premalignant prostate epithelia
journal, November 2002

Pierson, Christopher R.; McGowen, Richard; Grignon, David
The Prostate, Vol. 53, Issue 4
https://doi.org/10.1002/pros.10107

Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-κB and IκB kinase-α in human colorectal cancer epithelial cells
journal, May 2003

Charalambous, M. P.; Maihöfner, C.; Bhambra, U.
British Journal of Cancer, Vol. 88, Issue 10
https://doi.org/10.1038/sj.bjc.6600927

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Similar Records

Title: Method for detecting the presence of prostate cancer

Abstract

Citation Formats

Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin journal, March 2007

IκB kinase-α acts in the epidermis to control skeletal and craniofacial morphogenesis journal, April 2004

Maspin is up-regulated in premalignant prostate epithelia journal, November 2002

Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-κB and IκB kinase-α in human colorectal cancer epithelial cells journal, May 2003

Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin
journal, March 2007

IκB kinase-α acts in the epidermis to control skeletal and craniofacial morphogenesis
journal, April 2004

Maspin is up-regulated in premalignant prostate epithelia
journal, November 2002

Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-κB and IκB kinase-α in human colorectal cancer epithelial cells
journal, May 2003