Biological detector and method

Title: Biological detector and method

Abstract

A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

Inventors:: Sillerud, Laurel; Alam, Todd M.; McDowell, Andrew F.

Issue Date:: 2015-11-24

Research Org.:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1226815

Patent Number(s):: 9194921

Application Number:: 13/717,412

Assignee:: STC.UNM (Albuquerque, NM)

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/34092 - {RF coils specially adapted for NMR spectrometers}

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/553 - Metal or metal coated
G01N24/08 - by using nuclear magnetic resonance

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/32 - Excitation or detection systems, e.g. using radio frequency signals
G01R33/5601 - {involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent}
G01R33/281 - {Means for the use of in vitro contrast agents
G01R33/34007 - {Manufacture of RF coils, e.g. using printed circuit board technology

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/54326 - {Magnetic particles}

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/302 - {Miniaturized sample handling arrangements for sampling small quantities, e.g. flow-through microfluidic NMR chips}
G01R33/34046 - {Volume type coils, e.g. bird-cage coils

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
B82Y15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/465 - applied to biological material, e.g. in vitro testing
G01R33/341 - comprising surface coils

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DOE Contract Number:: AC04-94AL85000

Resource Type:: Patent

Resource Relation:: Patent File Date: 2012 Dec 17

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Sillerud, Laurel, Alam, Todd M., and McDowell, Andrew F. Biological detector and method.  United States: N. p., 2015. 
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                    Sillerud, Laurel, Alam, Todd M., & McDowell, Andrew F. Biological detector and method.  United States.

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                    Sillerud, Laurel, Alam, Todd M., and McDowell, Andrew F. Tue .  
        "Biological detector and method".  United States.  https://www.osti.gov/servlets/purl/1226815.

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@article{osti_1226815,

  title        = {Biological detector and method},

  author       = {Sillerud, Laurel and Alam, Todd M. and McDowell, Andrew F.},

  abstractNote = {A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2015},

  month        = {11}

}

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