skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Biological detector and method

Abstract

A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

Inventors:
; ;
Publication Date:
Research Org.:
SNL (Sandia National Laboratories (SNL), Albuquerque, NM
Sponsoring Org.:
USDOE
OSTI Identifier:
1082733
Patent Number(s):
8,384,381
Application Number:
12/720,499
Assignee:
STC . UNM (Albuquerque, NM)
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Sillerud, Laurel, Alam, Todd M, and McDowell, Andrew F. Biological detector and method. United States: N. p., 2013. Web.
Sillerud, Laurel, Alam, Todd M, & McDowell, Andrew F. Biological detector and method. United States.
Sillerud, Laurel, Alam, Todd M, and McDowell, Andrew F. 2013. "Biological detector and method". United States. https://www.osti.gov/servlets/purl/1082733.
@article{osti_1082733,
title = {Biological detector and method},
author = {Sillerud, Laurel and Alam, Todd M and McDowell, Andrew F},
abstractNote = {A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.},
doi = {},
url = {https://www.osti.gov/biblio/1082733}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 26 00:00:00 EST 2013},
month = {Tue Feb 26 00:00:00 EST 2013}
}

Works referenced in this record:

NMR device for detection of analytes
patent-application, May 2009


Microfluidic devices for high gradient magnetic separation
patent-application, January 2004


Design and Analysis of Microcoils for NMR Microscopy
journal, August 1995


Tuning Low-Inductance Coils at Low Frequencies
patent-application, October 2009


Solenoidal and planar microcoils for NMR spectroscopy
conference, January 2003


Microcoil Magnetic Resonance Detectors
patent-application, June 2009


NMR radiofrequency microcoil design: electromagnetic simulation usefulness.
journal, April 2002


Integrated On-Chip NMR and ESR Device and Method for Making and Using the Same
patent-application, July 2007


RF Microcoil Design for Practical NMR of Mass-Limited Samples
journal, July 1998


1H-NMR Spectroscopy on the Nanoliter Scale for Static and Online Measurements
journal, November 1994


Nuclear magnetic resonance analysis of multiple samples
patent-application, September 2002


Biological Detector and Method
patent-application, August 2008


Solvent mediated relaxation assay system
patent, November 1992


Portable NMR device and method for making and using the same
patent, March 2008


Nuclear magnetic resonance analysis of multiple samples
patent, February 2004


Detection with evanescent wave probe
patent-application, April 2007


Triaxial magnetic field gradient system for microcoil magnetic resonance imaging
journal, January 2000


Batch-fabricated gradient glossary
patent-application, December 2003


Towards nuclear magnetic resonance ÎĽ-spectroscopy and ÎĽ-imaging
journal, January 2004


Magneitc-nanoparticle conjugates and methods of use
patent-application, May 2003


Microcoil NMR Detectors
patent-application, November 2008


Reversible agglutination mediators
patent, August 1992


Method and apparatus for NMR spectroscopy of nanoliter volume samples
patent, August 1997


The signal-to-noise ratio of the nuclear magnetic resonance experiment
journal, October 1976


Chip–NMR biosensor for detection and molecular analysis of cells
journal, July 2008


Micro-spectrometer for NMR: analysis of small quantities in vitro
journal, March 2004


Microcoil magnetic resonance detectors
patent, March 2012


Development of low field nuclear magnetic resonance microcoils
journal, February 2005


Design and testing of high sensitivity microreceiver coil apparatus for nuclear magnetic resonance and imaging
journal, April 2001


One-Step, Nanoparticle-Mediated Bacterial Detection with Magnetic Relaxation
journal, February 2007


Catheter tracking with phase information
patent-application, November 2005


Microcoil based micro-NMR spectrometer and method
patent, August 2000


Microcoil Magnetic Resonance Detectors
patent-application, May 2012


1H NMR Detection of superparamagnetic nanoparticles at 1T using a microcoil and novel tuning circuit
journal, August 2006


NMR device for detection of analytes
patent-application, May 2007


Toroid cavity/coil NMR multi-detector
patent, September 2007


Operating nanoliter scale NMR microcoils in a 1 tesla field
journal, September 2007


Low-field MRI
patent, January 2005


Portable NMR device and method for making and using the same
patent-application, July 2007


Solvent mediated relaxation assay system
patent, October 1993


Method and device for determining an analyte in a sample
patent, June 1998


Miniature magnetic resonance machines
journal, October 1997


Multiparameter Magnetic Relaxation Switch Assays
journal, December 2007


Miniature permanent magnet for table-top NMR
journal, January 2003


Biological detector and method
patent-application, December 2008


Nanoparticles having oligonucleotides attached thereto and uses therefor
patent, March 2002


Microcoil based micro-NMR spectrometer and method
patent, September 2004


Planar microcoil-based magnetic resonance imaging of cells
conference, January 2003