Title: Biological detector and method

Abstract

A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

Inventors:

Sillerud, Laurel; Alam, Todd M.; McDowell, Andrew F.

Issue Date:

2018-05-01

Research Org.:

Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1438400

Patent Number(s):

9958516

Application Number:

14/226,572

Assignee:

ABQMR, Inc. (Albuquerque, NM); Sandia Corporation (Albuquerque, NM); STC.UNM (Albuquerque, NM)

Patent Classifications (CPCs):

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES

G01R33/34092 - {RF coils specially adapted for NMR spectrometers}

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/553 - Metal or metal coated
G01N24/08 - by using nuclear magnetic resonance

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES

G01R33/32 - Excitation or detection systems, e.g. using radio frequency signals
G01R33/5601 - {involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent}
G01R33/281 - {Means for the use of in vitro contrast agents
G01R33/34007 - {Manufacture of RF coils, e.g. using printed circuit board technology

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/54326 - {Magnetic particles}

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES

G01R33/302 - {Miniaturized sample handling arrangements for sampling small quantities, e.g. flow-through microfluidic NMR chips}
G01R33/34046 - {Volume type coils, e.g. bird-cage coils

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

B82Y15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES

G01R33/465 - applied to biological material, e.g. in vitro testing
G01R33/341 - comprising surface coils

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DOE Contract Number:  

AC04-94AL85000

Resource Type:

Patent

Resource Relation:

Patent File Date: 2014 Mar 26

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES