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Title: Biological detector and method

Abstract

A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

Inventors:
; ;
Issue Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1129189
Patent Number(s):
8698494
Application Number:
13/776,580
Assignee:
STC.UNM (Albuquerque, NM)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Resource Relation:
Patent File Date: 2013 Feb 25
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Sillerud, Laurel, Alam, Todd M, and McDowell, Andrew F. Biological detector and method. United States: N. p., 2014. Web.
Sillerud, Laurel, Alam, Todd M, & McDowell, Andrew F. Biological detector and method. United States.
Sillerud, Laurel, Alam, Todd M, and McDowell, Andrew F. Tue . "Biological detector and method". United States. https://www.osti.gov/servlets/purl/1129189.
@article{osti_1129189,
title = {Biological detector and method},
author = {Sillerud, Laurel and Alam, Todd M and McDowell, Andrew F},
abstractNote = {A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {4}
}

Works referenced in this record:

Reversible agglutination mediators
patent, August 1992


Solvent mediated relaxation assay system
patent, November 1992


Solvent mediated relaxation assay system
patent, October 1993


Detection of biological macromolecules by NMR-sensitive labels
patent, August 1994


Method and apparatus for NMR spectroscopy of nanoliter volume samples
patent, August 1997


Method and device for determining an analyte in a sample
patent, June 1998


Microcoil based micro-NMR spectrometer and method
patent, August 2000


Nanoparticles having oligonucleotides attached thereto and uses therefor
patent, March 2002


MR method utilizing microcoils situated in the examination zone
patent, May 2002


Device for high gain and uniformly localized magnetic resonance imaging
patent, November 2002


MR method for exciting the nuclear magnetization in a limited volume
patent, January 2003


Nuclear magnetic resonance analysis of multiple samples
patent, February 2004


Multistage electromagnetic separator for purifying cells, chemicals and protein structures
patent, March 2004


Microcoil based micro-NMR spectrometer and method
patent, September 2004


Low-field MRI
patent, January 2005


Nuclear magnetic resonance analysis of multiple samples
patent, October 2005


Method and apparatus for intracorporeal medical imaging using a self-tuned coil
patent, August 2006


Toroid cavity/coil NMR multi-detector
patent, September 2007


Integrated on-chip NMR and ESR device and method for making and using the same
patent, September 2007


Portable NMR device and method for making and using the same
patent, March 2008


Electron spin resonance microscope for imaging with micron resolution
patent, July 2008


Microcoil magnetic resonance detectors
patent, March 2012


NMR device for detection of analytes
patent, December 2012


Biological detector and method
patent, February 2013


Nuclear magnetic resonance analysis of multiple samples
patent-application, September 2002


Multistage electromagnetic separator for purifying cells, chemicals and protein structures
patent-application, October 2002


Magneitc-nanoparticle conjugates and methods of use
patent-application, May 2003


Batch-fabricated gradient glossary
patent-application, December 2003


Microfluidic devices for high gradient magnetic separation
patent-application, January 2004


Catheter tracking with phase information
patent-application, November 2005


Detection with evanescent wave probe
patent-application, April 2007


NMR device for detection of analytes
patent-application, May 2007


Integrated On-Chip NMR and ESR Device and Method for Making and Using the Same
patent-application, July 2007


Portable NMR device and method for making and using the same
patent-application, July 2007


Biological Detector and Method
patent-application, August 2008


Microcoil NMR Detectors
patent-application, November 2008


Biological detector and method
patent-application, December 2008


NMR device for detection of analytes
patent-application, May 2009


Guided transport of magnetically labeled biological molecules and cells
patent-application, June 2009


Microcoil Magnetic Resonance Detectors
patent-application, June 2009


Tuning Low-Inductance Coils at Low Frequencies
patent-application, October 2009


System and Method for Detecting Labeled Entities Using Microcoil Magnetic MRI
patent-application, August 2010


Microcoil Magnetic Resonance Detectors
patent-application, May 2012


Biological Detector and Method
patent-application, May 2013


Solenoidal and planar microcoils for NMR spectroscopy
conference, January 2003


Development of low field nuclear magnetic resonance microcoils
journal, February 2005


The signal-to-noise ratio of the nuclear magnetic resonance experiment
journal, October 1976


One-Step, Nanoparticle-Mediated Bacterial Detection with Magnetic Relaxation
journal, February 2007


Chip–NMR biosensor for detection and molecular analysis of cells
journal, July 2008


Planar microcoil-based magnetic resonance imaging of cells
conference, January 2003


Operating nanoliter scale NMR microcoils in a 1 tesla field
journal, September 2007


Solenoidal microcoil design. Part I: Optimizing RF homogeneity and coil dimensions
journal, January 2001


Miniature permanent magnet for table-top NMR
journal, January 2003


Design and Analysis of Microcoils for NMR Microscopy
journal, August 1995


RF microcoils patterned using microlithographic techniques for use as microsensors in NMR
conference, January 1993


Design and testing of high sensitivity microreceiver coil apparatus for nuclear magnetic resonance and imaging
journal, April 2001


Triaxial magnetic field gradient system for microcoil magnetic resonance imaging
journal, January 2000


1H NMR Detection of superparamagnetic nanoparticles at 1T using a microcoil and novel tuning circuit
journal, August 2006


Micro-spectrometer for NMR: analysis of small quantities in vitro
journal, March 2004


RF Microcoil Design for Practical NMR of Mass-Limited Samples
journal, July 1998


Multiparameter Magnetic Relaxation Switch Assays
journal, December 2007


NMR radiofrequency microcoil design: electromagnetic simulation usefulness.
journal, April 2002


Miniature magnetic resonance machines
journal, October 1997


Towards nuclear magnetic resonance μ-spectroscopy and μ-imaging
journal, January 2004


    Works referencing / citing this record:

    Biological detector and method
    patent, November 2015