Biological detector and method

Title: Biological detector and method

Abstract

A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

Inventors:: Sillerud, Laurel; Alam, Todd M; McDowell, Andrew F

Issue Date:: 2014-04-15

Research Org.:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1129189

Patent Number(s):: 8698494

Application Number:: 13/776,580

Assignee:: STC.UNM (Albuquerque, NM)

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

Show more

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/34092 - {RF coils specially adapted for NMR spectrometers}

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/553 - Metal or metal coated
G01N24/08 - by using nuclear magnetic resonance

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/32 - Excitation or detection systems, e.g. using radio frequency signals
G01R33/5601 - {involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent}
G01R33/281 - {Means for the use of in vitro contrast agents
G01R33/34007 - {Manufacture of RF coils, e.g. using printed circuit board technology

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/54326 - {Magnetic particles}

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/302 - {Miniaturized sample handling arrangements for sampling small quantities, e.g. flow-through microfluidic NMR chips}
G01R33/34046 - {Volume type coils, e.g. bird-cage coils

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
B82Y15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/465 - applied to biological material, e.g. in vitro testing
G01R33/341 - comprising surface coils

Show less

DOE Contract Number:: AC04-94AL85000

Resource Type:: Patent

Resource Relation:: Patent File Date: 2013 Feb 25

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Sillerud, Laurel, Alam, Todd M, and McDowell, Andrew F. Biological detector and method.  United States: N. p., 2014. 
        Web.

Copy to clipboard


                    Sillerud, Laurel, Alam, Todd M, & McDowell, Andrew F. Biological detector and method.  United States.

Copy to clipboard


                    Sillerud, Laurel, Alam, Todd M, and McDowell, Andrew F. Tue .  
        "Biological detector and method".  United States.  https://www.osti.gov/servlets/purl/1129189.

Copy to clipboard


                    
@article{osti_1129189,

  title        = {Biological detector and method},

  author       = {Sillerud, Laurel and Alam, Todd M and McDowell, Andrew F},

  abstractNote = {A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2014},

  month        = {4}

}

Copy to clipboard

Patent:

View Patent

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Nuclear magnetic resonance net organic flowmeter
patent, February 1990

Lew, Hyok
US Patent Document 4,901,018
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F4901018

Reversible agglutination mediators
patent, August 1992

Tarnowski, Thomas; Lin, Cheng-I; Ullman, Edwin
US Patent Document 5,136,095
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F5136095

Solvent mediated relaxation assay system
patent, November 1992

Josephson, Lee; Menz, Edward; Groman, Ernest
US Patent Document 5,164,297
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F5164297

Solvent mediated relaxation assay system
patent, October 1993

Josephson, Lee; Menz, Edward; Groman, Ernest
US Patent Document 5,254,460
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F5254460

Detection of biological macromolecules by NMR-sensitive labels
patent, August 1994

Lee, Lawrence; Gautsch, James
US Patent Document 5,338,687
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F5338687

Method and apparatus for NMR spectroscopy of nanoliter volume samples
patent, August 1997

Sweedler, Jonathan; Peck, Timothy; Webb, Andrew
US Patent Document 5,654,636
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F5654636

Dry chemistry cascade immunoassay and affinity assay
patent, October 1997

Oberhardt, Bruce
US Patent Document 5,677,133
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F5677133

Apparatus and method for compensation of magnetic susceptibility variation in NMR microspectroscopy detection microcoils
patent, November 1997

Peck, Timothy; Olson, Dean; Sweedler, Jonathan
US Patent Document 5,684,401
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F5684401

Variable external capacitor for NMR probe
patent, June 1998

Finnigan, James
US Patent Document 5,768,089
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F5768089

Method and device for determining an analyte in a sample
patent, June 1998

Colin, Bruno; Goudard, Michel; Theretz, Alain
US Patent Document 5,773,307
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F5773307

Method and device for the determination of an analyte using super paramagnetic reactive particles
patent, July 1999

Colin, Bruno; Theretz, Alain
US Patent Document 5,925,573
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F5925573

Microcoil based micro-NMR spectrometer and method
patent, August 2000

Sweedler, Jonathan; Magin, Richard; Peck, Timothy
US Patent Document 6,097,188
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6097188

Integrated miniaturized device for processing and NMR detection of liquid phase samples
patent, February 2001

Freeman, Dominique; Swedberg, Sally
US Patent Document 6,194,900
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6194900

MR device provided with a medical instrument, and method of determining the position of the medical instrument
patent, May 2001

Ludeke, Kai-Michael; Rasche, Volker
US Patent Document 6,236,205
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6236205

Field-frequency lock system for magnetic resonance system
patent, June 2001

Hurd, Ralph
US Patent Document 6,242,915
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6242915

Methods for high throughput chemical screening using magnetic resonance imaging
patent, October 2001

Sugarman, Jeffrey; Star-Lack, Joshua
US Patent Document 6,307,372
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6307372

NMR of thin layers using a meanderline surface coil
patent, December 2001

Cowgill, Donald
US Patent Document 6,326,787
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6326787

Nanoparticles having oligonucleotides attached thereto and uses therefor
patent, March 2002

Mirkin, Chad; Letsinger, Robert; Mucic, Robert
US Patent Document 6,361,944
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6361944

MR method utilizing microcoils situated in the examination zone
patent, May 2002

Ludeke, Kai-Michael; Rasche, Volker
US Patent Document 6,397,094
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6397094

Method and apparatus for simultaneous acquisition of high resolution NMR spectra from multiple samples
patent, September 2002

Webb, Andrew; Sweedler, Jonathan
US Patent Document 6,456,072
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6456072

Device for high gain and uniformly localized magnetic resonance imaging
patent, November 2002

Viswanathan, Raju; Raghavan, Raghu
US Patent Document 6,487,437
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6487437

MR method for exciting the nuclear magnetization in a limited volume
patent, January 2003

Weiss, Steffen; Ludeke, Kai-Michael
US Patent Document 6,512,941
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6512941

Microcoil device with a forward field-of-view for large gain magnetic resonance imaging
patent, July 2003

Viswanathan, Raju
US Patent Document 6,587,706
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6587706

Method and apparatus for generating controlled torques on objects particularly objects inside a living body
patent, July 2003

Nevo, Erez
US Patent Document 6,594,517
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6594517

Nuclear magnetic resonance analysis of multiple samples
patent, February 2004

Raftery, Daniel; Fisher, George; McNamara, Ernesto
US Patent Document 6,696,838
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6696838

Multistage electromagnetic separator for purifying cells, chemicals and protein structures
patent, March 2004

Vellinger, John; Todd, Paul; Barton, Kenneth
US Patent Document 6,699,669
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6699669

Microcoil based micro-NMR spectrometer and method
patent, September 2004

Sweedler, Jonathan; Magin, Richard; Peck, Timothy
US Patent Document 6,788,061
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6788061

Microfluidic device with multiple microcoil NMR detectors and field gradient focusing
patent, November 2004

Peck, Tim; Olson, Dean; Norcross, Jim
US Patent Document 6,822,454
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6822454

Low-field MRI
patent, January 2005

Albert, Mitchell; Balamore, Dilip; Venkatesh, Arvind
US Patent Document 6,845,262
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6845262

Nuclear magnetic resonance analysis of multiple samples
patent, October 2005

Raftery, Daniel; McNamara, Ernesto
US Patent Document 6,958,609
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6958609

Method and apparatus for intracorporeal medical imaging using a self-tuned coil
patent, August 2006

Hockett, Frank; Wickline, Samuel; Yu, Xin
US Patent Document 7,096,057
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F7096057

Microfluidic device with multiple microcoil NMR detectors enabling fluidic series communication
patent, November 2006

Peck, Tim; Olson, Dean; Norcross, Jim
US Patent Document 7,141,978
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F7141978

Localized two-dimensional shift correlated MR spectroscopy of human brain
patent, April 2007

Thomas, Michael; Yue, Kenneth
US Patent Document 7,200,430
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F7200430

Anisotropic nanoparticle amplification of magnetic resonance signals
patent, April 2007

Barbic, Mladen
US Patent Document 7,202,667
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F7202667

Toroid cavity/coil NMR multi-detector
patent, September 2007

Gerald, Rex; Meadows, Alexander; Gregar, Joseph
US Patent Document 7,271,592
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F7271592

Integrated on-chip NMR and ESR device and method for making and using the same
patent, September 2007

Park, Chang-Min; Ramanathan, Shriram; Morrow, Patrick
US Patent Document 7,274,191
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F7274191

Portable NMR device and method for making and using the same
patent, March 2008

Park, Chang-Min; Ramanathan, Shriram; Morrow, Patrick
US Patent Document 7,345,479
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F7345479

Electron spin resonance microscope for imaging with micron resolution
patent, July 2008

Blank, Aharon; Dunnam, Curt; Borbat, Peter
US Patent Document 7,403,008
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F7403008

Tuning low-inductance coils at low frequencies
patent, July 2008

McDowell, Andrew
US Patent Document 7,405,567
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F7405567

NMR device for detection of analytes
patent, July 2009

Lee, W. David
US Patent Document 7,564,245
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F7564245

Microcoil magnetic resonance detectors
patent, March 2012

McDowell, Andrew; Fukushima, Eiichi; Esch, Victor
US Patent Document 8,143,896
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F8143896

NMR device for detection of analytes
patent, December 2012

Lee, W. David
US Patent Document 8,334,693
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F8334693