Method for photo-altering a biological system to improve biological effect
Abstract
Photodynamic therapy is a new adjunctive therapy for filtration surgery that does not use chemotherapy agents or radiation, but uses pharmacologically-active sensitizing compounds to produce a titratable, localized, transient, post operative avascular conjunctiva. A photosensitizing agent in a biological system is selectively activated by delivering the photosensitive agent to the biological system and laser activating only a spatially selected portion of the delivered photosensitive agent. The activated portion of the photosensitive agent reacts with the biological system to obtain a predetermined biological effect. As a result, an improved spatial disposition and effectuation of the biological effect by the photosensitive agent in the biological system is achieved.
- Inventors:
-
- Irvine, CA
- Santa Ynez, CA
- Santa Barbara, CA
- Issue Date:
- OSTI Identifier:
- 873120
- Patent Number(s):
- 6095147
- Application Number:
- 08/347,956
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61F - FILTERS IMPLANTABLE INTO BLOOD VESSELS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- 44514322443
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- method; photo-altering; biological; improve; effect; photodynamic; therapy; adjunctive; filtration; surgery; chemotherapy; agents; radiation; pharmacologically-active; sensitizing; compounds; produce; titratable; localized; transient; post; operative; avascular; conjunctiva; photosensitizing; agent; selectively; activated; delivering; photosensitive; laser; activating; spatially; selected; portion; delivered; reacts; obtain; predetermined; result; improved; spatial; disposition; effectuation; achieved; selected portion; photodynamic therapy; selectively activated; improved spatial; selectively activate; activated portion; /128/604/
Citation Formats
Hill, Richard A, Doiron, Daniel R, and Crean, David H. Method for photo-altering a biological system to improve biological effect. United States: N. p., 2000.
Web.
Hill, Richard A, Doiron, Daniel R, & Crean, David H. Method for photo-altering a biological system to improve biological effect. United States.
Hill, Richard A, Doiron, Daniel R, and Crean, David H. Tue .
"Method for photo-altering a biological system to improve biological effect". United States. https://www.osti.gov/servlets/purl/873120.
@article{osti_873120,
title = {Method for photo-altering a biological system to improve biological effect},
author = {Hill, Richard A and Doiron, Daniel R and Crean, David H},
abstractNote = {Photodynamic therapy is a new adjunctive therapy for filtration surgery that does not use chemotherapy agents or radiation, but uses pharmacologically-active sensitizing compounds to produce a titratable, localized, transient, post operative avascular conjunctiva. A photosensitizing agent in a biological system is selectively activated by delivering the photosensitive agent to the biological system and laser activating only a spatially selected portion of the delivered photosensitive agent. The activated portion of the photosensitive agent reacts with the biological system to obtain a predetermined biological effect. As a result, an improved spatial disposition and effectuation of the biological effect by the photosensitive agent in the biological system is achieved.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 01 00:00:00 EDT 2000},
month = {Tue Aug 01 00:00:00 EDT 2000}
}
Works referenced in this record:
ACTION SPECTRUM (620–640 nm) FOR HEMATOPORPHYRIN DERIVATIVE INDUCED CELL KILLING
journal, March 1984
- Gomer, Charles J.; Doiron, Daniel R.; Rucker, Natalie
- Photochemistry and Photobiology, Vol. 39, Issue 3