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Title: Method for photo-altering a biological system to improve biological effect

Abstract

Photodynamic therapy is a new adjunctive therapy for filtration surgery that does not use chemotherapy agents or radiation, but uses pharmacologically-active sensitizing compounds to produce a titratable, localized, transient, post operative avascular conjunctiva. A photosensitizing agent in a biological system is selectively activated by delivering the photosensitive agent to the biological system and laser activating only a spatially selected portion of the delivered photosensitive agent. The activated portion of the photosensitive agent reacts with the biological system to obtain a predetermined biological effect. As a result, an improved spatial disposition and effectuation of the biological effect by the photosensitive agent in the biological system is achieved.

Inventors:
 [1];  [2];  [3]
  1. Irvine, CA
  2. Santa Ynez, CA
  3. Santa Barbara, CA
Issue Date:
OSTI Identifier:
873120
Patent Number(s):
6095147
Application Number:
08/347,956
Assignee:
Regents of University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61F - FILTERS IMPLANTABLE INTO BLOOD VESSELS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
DOE Contract Number:  
44514322443
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; photo-altering; biological; improve; effect; photodynamic; therapy; adjunctive; filtration; surgery; chemotherapy; agents; radiation; pharmacologically-active; sensitizing; compounds; produce; titratable; localized; transient; post; operative; avascular; conjunctiva; photosensitizing; agent; selectively; activated; delivering; photosensitive; laser; activating; spatially; selected; portion; delivered; reacts; obtain; predetermined; result; improved; spatial; disposition; effectuation; achieved; selected portion; photodynamic therapy; selectively activated; improved spatial; selectively activate; activated portion; /128/604/

Citation Formats

Hill, Richard A, Doiron, Daniel R, and Crean, David H. Method for photo-altering a biological system to improve biological effect. United States: N. p., 2000. Web.
Hill, Richard A, Doiron, Daniel R, & Crean, David H. Method for photo-altering a biological system to improve biological effect. United States.
Hill, Richard A, Doiron, Daniel R, and Crean, David H. Tue . "Method for photo-altering a biological system to improve biological effect". United States. https://www.osti.gov/servlets/purl/873120.
@article{osti_873120,
title = {Method for photo-altering a biological system to improve biological effect},
author = {Hill, Richard A and Doiron, Daniel R and Crean, David H},
abstractNote = {Photodynamic therapy is a new adjunctive therapy for filtration surgery that does not use chemotherapy agents or radiation, but uses pharmacologically-active sensitizing compounds to produce a titratable, localized, transient, post operative avascular conjunctiva. A photosensitizing agent in a biological system is selectively activated by delivering the photosensitive agent to the biological system and laser activating only a spatially selected portion of the delivered photosensitive agent. The activated portion of the photosensitive agent reacts with the biological system to obtain a predetermined biological effect. As a result, an improved spatial disposition and effectuation of the biological effect by the photosensitive agent in the biological system is achieved.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {8}
}

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Works referenced in this record:

ACTION SPECTRUM (620–640 nm) FOR HEMATOPORPHYRIN DERIVATIVE INDUCED CELL KILLING
journal, March 1984