Biological detector and method

Sillerud, Laurel; Alam, Todd M; McDowell, Andrew F

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Title: Biological detector and method

Abstract

A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

Inventors:: Sillerud, Laurel; Alam, Todd M; McDowell, Andrew F

Issue Date:: Tue Feb 26 00:00:00 EST 2013

Research Org.:: SNL (Sandia National Laboratories (SNL), Albuquerque, NM

Sponsoring Org.:: USDOE

OSTI Identifier:: 1082733

Patent Number(s):: 8384381

Application Number:: 12/720,499

Assignee:: STC . UNM (Albuquerque, NM)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
B82Y15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N24/08 - by using nuclear magnetic resonance
G01N33/54326 - {Magnetic particles}
G01N33/553 - Metal or metal coated

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/281 - {Means for the use of in vitro contrast agents
G01R33/302 - {Miniaturized sample handling arrangements for sampling small quantities, e.g. flow-through microfluidic NMR chips}
G01R33/32 - Excitation or detection systems, e.g. using radio frequency signals
G01R33/34007 - {Manufacture of RF coils, e.g. using printed circuit board technology
G01R33/34046 - {Volume type coils, e.g. bird-cage coils
G01R33/34092 - {RF coils specially adapted for NMR spectrometers}
G01R33/341 - comprising surface coils
G01R33/465 - applied to biological material, e.g. in vitro testing
G01R33/5601 - {involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent}

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DOE Contract Number:: AC04-94AL85000

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

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                    Sillerud, Laurel, Alam, Todd M, and McDowell, Andrew F. Biological detector and method.  United States: N. p., 2013. 
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                    Sillerud, Laurel, Alam, Todd M, & McDowell, Andrew F. Biological detector and method.  United States.

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                    Sillerud, Laurel, Alam, Todd M, and McDowell, Andrew F. Tue .  
        "Biological detector and method".  United States.  https://www.osti.gov/servlets/purl/1082733.

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@article{osti_1082733,

  title        = {Biological detector and method},

  author       = {Sillerud, Laurel and Alam, Todd M and McDowell, Andrew F},

  abstractNote = {A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Feb 26 00:00:00 EST 2013},

  month        = {Tue Feb 26 00:00:00 EST 2013}

}

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