Method for determining gene knockouts
Abstract
A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a bioengineering objective for the organism, selecting at least one cellular objective, forming an optimization problem that couples the at least one cellular objective with the bioengineering objective, and solving the optimization problem to yield at least one candidate.
- Inventors:
- Issue Date:
- Research Org.:
- The Penn State Research Foundation (University Park, PA)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1084350
- Patent Number(s):
- 8457941
- Application Number:
- 13/210,484
- Assignee:
- The Penn State Research Foundation (University Park, PA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16B - BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- DOE Contract Number:
- FG03-01ER25499
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Maranas, Costa D, Burgard, Anthony R, and Pharkya, Priti. Method for determining gene knockouts. United States: N. p., 2013.
Web.
Maranas, Costa D, Burgard, Anthony R, & Pharkya, Priti. Method for determining gene knockouts. United States.
Maranas, Costa D, Burgard, Anthony R, and Pharkya, Priti. Tue .
"Method for determining gene knockouts". United States. https://www.osti.gov/servlets/purl/1084350.
@article{osti_1084350,
title = {Method for determining gene knockouts},
author = {Maranas, Costa D and Burgard, Anthony R and Pharkya, Priti},
abstractNote = {A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a bioengineering objective for the organism, selecting at least one cellular objective, forming an optimization problem that couples the at least one cellular objective with the bioengineering objective, and solving the optimization problem to yield at least one candidate.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jun 04 00:00:00 EDT 2013},
month = {Tue Jun 04 00:00:00 EDT 2013}
}
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