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Title: Methods and compositions for controlling gene expression by RNA processing

The present disclosure provides nucleic acids encoding an RNA recognition sequence positioned proximal to an insertion site for the insertion of a sequence of interest; and host cells genetically modified with the nucleic acids. The present disclosure also provides methods of modifying the activity of a target RNA, and kits and compositions for carrying out the methods.
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Issue Date:
OSTI Identifier:
The Regents of the University of California LBNL
Patent Number(s):
Application Number:
Contract Number:
Resource Relation:
Patent File Date: 2014 Apr 09
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
Country of Publication:
United States

Works referenced in this record:

Characterization of CRISPR RNA processing in Clostridium thermocellum and Methanococcus maripaludis
journal, August 2012
  • Richter, Hagen; Zoephel, Judith; Schermuly, Jeanette
  • Nucleic Acids Research, Vol. 40, Issue 19, p. 9887-9896
  • DOI: 10.1093/nar/gks737

Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease
journal, September 2010
  • Haurwitz, R. E.; Jinek, M.; Wiedenheft, B.
  • Science, Vol. 329, Issue 5997, p. 1355-1358
  • DOI: 10.1126/science.1192272

Kinetics of Paused Ribosome Recycling in Escherichia coli
journal, November 2009
  • Janssen, Brian D.; Hayes, Christopher S.
  • Journal of Molecular Biology, Vol. 394, Issue 2, p. 251-267
  • DOI: 10.1016/j.jmb.2009.09.020

Versatile RNA-sensing transcriptional regulators for engineering genetic networks
journal, May 2011
  • Lucks, J. B.; Qi, L.; Mutalik, V. K.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 21, p. 8617-8622
  • DOI: 10.1073/pnas.1015741108

Evolution and classification of the CRISPR–Cas systems
journal, May 2011
  • Makarova, Kira S.; Haft, Daniel H.; Barrangou, Rodolphe
  • Nature Reviews Microbiology, Vol. 9, Issue 6, p. 467-477
  • DOI: 10.1038%2Fnrmicro2577

Rationally designed families of orthogonal RNA regulators of translation
journal, March 2012
  • Mutalik, Vivek K.; Qi, Lei; Guimaraes, Joao C.
  • Nature Chemical Biology, Vol. 8, Issue 5, p. 447-454
  • DOI: 10.1038/nchembio.919