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Title: Methods and compositions for controlling gene expression by RNA processing

Abstract

The present disclosure provides nucleic acids encoding an RNA recognition sequence positioned proximal to an insertion site for the insertion of a sequence of interest; and host cells genetically modified with the nucleic acids. The present disclosure also provides methods of modifying the activity of a target RNA, and kits and compositions for carrying out the methods.

Inventors:
; ; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1377877
Patent Number(s):
9745610
Application Number:
14/248,980
Assignee:
The Regents of the University of California
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Apr 09
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Doudna, Jennifer A., Qi, Lei S., Haurwitz, Rachel E., and Arkin, Adam P. Methods and compositions for controlling gene expression by RNA processing. United States: N. p., 2017. Web.
Doudna, Jennifer A., Qi, Lei S., Haurwitz, Rachel E., & Arkin, Adam P. Methods and compositions for controlling gene expression by RNA processing. United States.
Doudna, Jennifer A., Qi, Lei S., Haurwitz, Rachel E., and Arkin, Adam P. Tue . "Methods and compositions for controlling gene expression by RNA processing". United States. https://www.osti.gov/servlets/purl/1377877.
@article{osti_1377877,
title = {Methods and compositions for controlling gene expression by RNA processing},
author = {Doudna, Jennifer A. and Qi, Lei S. and Haurwitz, Rachel E. and Arkin, Adam P.},
abstractNote = {The present disclosure provides nucleic acids encoding an RNA recognition sequence positioned proximal to an insertion site for the insertion of a sequence of interest; and host cells genetically modified with the nucleic acids. The present disclosure also provides methods of modifying the activity of a target RNA, and kits and compositions for carrying out the methods.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {8}
}

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Works referenced in this record:

Characterization of CRISPR RNA processing in Clostridium thermocellum and Methanococcus maripaludis
journal, August 2012


Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease
journal, September 2010


Kinetics of Paused Ribosome Recycling in Escherichia coli
journal, November 2009


Versatile RNA-sensing transcriptional regulators for engineering genetic networks
journal, May 2011


Evolution and classification of the CRISPR–Cas systems
journal, May 2011


Rationally designed families of orthogonal RNA regulators of translation
journal, March 2012