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Title: Method for determining gene knockouts

Abstract

A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a bioengineering objective for the organism, selecting at least one cellular objective, forming an optimization problem that couples the at least one cellular objective with the bioengineering objective, and solving the optimization problem to yield at least one candidate.

Inventors:
 [1];  [2];  [2]
  1. Port Matilda, PA
  2. State College, PA
Issue Date:
Research Org.:
Genomatica Inc
Sponsoring Org.:
USDOE
OSTI Identifier:
1027107
Patent Number(s):
8027821
Application Number:
US patent applicaiton 10/616,659
Assignee:
The Penn State Research Foundation (University Park, PA)
Patent Classifications (CPCs):
G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16B - BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
FG03-01ER25499
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Maranas, Costas D, Burgard, Anthony R, and Pharkya, Priti. Method for determining gene knockouts. United States: N. p., 2011. Web.
Maranas, Costas D, Burgard, Anthony R, & Pharkya, Priti. Method for determining gene knockouts. United States.
Maranas, Costas D, Burgard, Anthony R, and Pharkya, Priti. Tue . "Method for determining gene knockouts". United States. https://www.osti.gov/servlets/purl/1027107.
@article{osti_1027107,
title = {Method for determining gene knockouts},
author = {Maranas, Costas D and Burgard, Anthony R and Pharkya, Priti},
abstractNote = {A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a bioengineering objective for the organism, selecting at least one cellular objective, forming an optimization problem that couples the at least one cellular objective with the bioengineering objective, and solving the optimization problem to yield at least one candidate.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {9}
}

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