Method for determining gene knockouts

Maranas, Costas D; Burgard, Anthony R; Pharkya, Priti

Title: Method for determining gene knockouts

Patent · Tue Sep 27 00:00:00 EDT 2011

OSTI ID:1027107

Maranas, Costas D ^[1]; Burgard, Anthony R ^[2]; Pharkya, Priti ^[2]

Port Matilda, PA
State College, PA

A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a bioengineering objective for the organism, selecting at least one cellular objective, forming an optimization problem that couples the at least one cellular objective with the bioengineering objective, and solving the optimization problem to yield at least one candidate.

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Research Organization:: Genomatica Inc

Sponsoring Organization:: USDOE

DOE Contract Number:: FG03-01ER25499

Assignee:: The Penn State Research Foundation (University Park, PA)

Patent Number(s):: 8,027,821

Application Number:: US patent applicaiton 10/616,659

OSTI ID:: 1027107

Country of Publication:: United States

Language:: English

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