Positron emission tomographic imaging of tumors using monoclonal antibodies

Technical Report · Sat Aug 01 00:00:00 EDT 1992

DOI:https://doi.org/10.2172/7044962· OSTI ID:7044962

Zalutsky, M R

This research project is developing methods for utilizing positron emission tomography (PET) to increase the clinical potential of radiolabeled monoclonal antibodies (MAbs). This report describes the development of methods for labeling MAbs and their fragments with positron-emitting halogen nuclides, fluorine-18 and iodine-124. These nulides were selected because of the widespread availability of F-18 and because of our extensive experience in the development of new protein radiohalogenation methods.

• Research Organization: Duke Univ. Medical Center, Durham, NC (United States). Dept. of Radiology
• Sponsoring Organization: USDOE; USDOE, Washington, DC (United States)
• DOE Contract Number: FG05-89ER60789
• OSTI ID: 7044962
• Report Number(s): DOE/ER/60789-4; ON: DE92018599
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
MONOCLONAL ANTIBODIES
LABELLING
MYOCARDIAL INFARCTION
POSITRON COMPUTED TOMOGRAPHY
RADIOIMMUNOSCINTIGRAPHY
DOGS
FLUORINE 18
IODINE 124
MYOSIN
PROGRESS REPORT
RADIOCHEMISTRY
RADIOPHARMACEUTICALS
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARDIOVASCULAR DISEASES
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
GLOBULINS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
NANOSEC LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOIMMUNODETECTION
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TOMOGRAPHY
TRACER TECHNIQUES
VERTEBRATES
550602* - Medicine- External Radiation in Diagnostics- (1980-)
400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production