Positron emission tomographic imaging of tumors using monoclonal antibodies

Technical Report · Fri Dec 01 00:00:00 EST 1989

OSTI ID:5024623

Zalutsky, M R ^[1]

---

1. Duke Univ., Durham, NC (USA). Dept. of Radiology

The overall objective of this research project is to develop methods for utilizing positron emission tomography (PET) to increase the clinical potential of radiolabeled monoclonal antibodies (MAbs). Both diagnostic and therapeutic applications of labeled MAbs could be improved as a result of knowledge obtained through the exploitation of the advantageous imaging characteristics associated with PET. By labeling MAbs with positron-emitting nuclides, it should be possible to quantitate the dynamics of their three-dimensional distribution in vivo. Our long-term goals are to apply this approach. 3 tabs.

• Research Organization: Duke Univ., Durham, NC (USA). Dept. of Radiology
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG05-89ER60789
• OSTI ID: 5024623
• Report Number(s): DOE/ER/60789-1; ON: DE90004645; TRN: 90-026361
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
IMAGE PROCESSING
OPTIMIZATION
NEOPLASMS
RADIOIMMUNOSCINTIGRAPHY
ANTIGEN-ANTIBODY REACTIONS
BROMINE 75
BROMINE 76
DIAGNOSTIC TECHNIQUES
FLUORINE 18
MONOCLONAL ANTIBODIES
POSITRON COMPUTED TOMOGRAPHY
PROGRESS REPORT
RADIOIMMUNOTHERAPY
THERAPEUTIC USES
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BROMINE ISOTOPES
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DISEASES
DOCUMENT TYPES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
IMMUNOLOGY
IMMUNOTHERAPY
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
PROCESSING
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SCINTISCANNING
THERAPY
TOMOGRAPHY
TRACER TECHNIQUES
USES
560160* - Radionuclide Effects
Kinetics
& Toxicology