Positron emission tomographic imaging of tumors using monoclonal antibodies. Progress report, April 15, 1992--October 31, 1992

Technical Report · Sat Aug 01 04:00:00 EDT 1992

DOI:https://doi.org/10.2172/10168353· OSTI ID:10168353

Zalutsky, M R

This research project is developing methods for utilizing positron emission tomography (PET) to increase the clinical potential of radiolabeled monoclonal antibodies (MAbs). This report describes the development of methods for labeling MAbs and their fragments with positron-emitting halogen nuclides, fluorine-18 and iodine-124. These nulides were selected because of the widespread availability of F-18 and because of our extensive experience in the development of new protein radiohalogenation methods.

• Research Organization: Duke Univ. Medical Center, Durham, NC (United States). Dept. of Radiology
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG05-89ER60789
• OSTI ID: 10168353
• Report Number(s): DOE/ER/60789--4; ON: DE92018599
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703
550602
62 RADIOLOGY AND NUCLEAR MEDICINE
DOGS
EXTERNAL RADIATION IN DIAGNOSTICS
FLUORINE 18
IODINE 124
LABELLING
MONOCLONAL ANTIBODIES
MYOCARDIAL INFARCTION
MYOSIN
POSITRON COMPUTED TOMOGRAPHY
PROGRESS REPORT
RADIOCHEMISTRY
RADIOIMMUNOSCINTIGRAPHY
RADIOISOTOPE PRODUCTION
RADIOPHARMACEUTICALS