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Title: Positron emission tomographic imaging of tumors using monoclonal antibodies

Abstract

This research project is developing methods for utilizing positron emission tomography (PET) to increase the clinical potential of radiolabeled monoclonal antibodies (MAbs). This report describes the development of methods for labeling MAbs and their fragments with positron-emitting halogen nuclides, fluorine-18 and iodine-124. These nulides were selected because of the widespread availability of F-18 and because of our extensive experience in the development of new protein radiohalogenation methods.

Authors:
Publication Date:
Research Org.:
Duke Univ. Medical Center, Durham, NC (United States). Dept. of Radiology
Sponsoring Org.:
USDOE; USDOE, Washington, DC (United States)
OSTI Identifier:
7044962
Report Number(s):
DOE/ER/60789-4
ON: DE92018599
DOE Contract Number:  
FG05-89ER60789
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; MONOCLONAL ANTIBODIES; LABELLING; MYOCARDIAL INFARCTION; POSITRON COMPUTED TOMOGRAPHY; RADIOIMMUNOSCINTIGRAPHY; DOGS; FLUORINE 18; IODINE 124; MYOSIN; PROGRESS REPORT; RADIOCHEMISTRY; RADIOPHARMACEUTICALS; ANIMALS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARDIOVASCULAR DISEASES; CHEMISTRY; COMPUTERIZED TOMOGRAPHY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DOCUMENT TYPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; GLOBULINS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; NANOSEC LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; PROTEINS; RADIOIMMUNODETECTION; RADIOISOTOPE SCANNING; RADIOISOTOPES; SCINTISCANNING; TOMOGRAPHY; TRACER TECHNIQUES; VERTEBRATES; 550602* - Medicine- External Radiation in Diagnostics- (1980-); 400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production

Citation Formats

Zalutsky, M R. Positron emission tomographic imaging of tumors using monoclonal antibodies. United States: N. p., 1992. Web. doi:10.2172/7044962.
Zalutsky, M R. Positron emission tomographic imaging of tumors using monoclonal antibodies. United States. https://doi.org/10.2172/7044962
Zalutsky, M R. 1992. "Positron emission tomographic imaging of tumors using monoclonal antibodies". United States. https://doi.org/10.2172/7044962. https://www.osti.gov/servlets/purl/7044962.
@article{osti_7044962,
title = {Positron emission tomographic imaging of tumors using monoclonal antibodies},
author = {Zalutsky, M R},
abstractNote = {This research project is developing methods for utilizing positron emission tomography (PET) to increase the clinical potential of radiolabeled monoclonal antibodies (MAbs). This report describes the development of methods for labeling MAbs and their fragments with positron-emitting halogen nuclides, fluorine-18 and iodine-124. These nulides were selected because of the widespread availability of F-18 and because of our extensive experience in the development of new protein radiohalogenation methods.},
doi = {10.2172/7044962},
url = {https://www.osti.gov/biblio/7044962}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Aug 01 00:00:00 EDT 1992},
month = {Sat Aug 01 00:00:00 EDT 1992}
}