Nuclear medicine progress report for quarter ending March 31, 1987

Technical Report · Sat Aug 01 04:00:00 EDT 1987

DOI:https://doi.org/10.2172/5977304· OSTI ID:5977304

Knapp, Jr., F. F.; Ambrose, K. R.; Srivastava, P. C.

Studies using Langendorff-perfused rat hearts have shown for the first time the formation of a polar metabolite from the methyl-branched fatty acid, BMIPP. Evaluation of the radioactive components in the outflow tract of hearts after administration of the straight-chain analogue (I-131)IPPA and (I-125)BMIPP were pursued. Analysis of lipid extracts by thin-layer chromatography illustrated the presence of a product considerably more polar than BMIPP. These results suggest for the first time that the slow myocardial clearance observed with BMIPP in clinical studies may be associated with the wash-out of an unidentified metabolite. As a continuation of an evaluation of the effects of tellurium (Te) heteroatom position and the position of alkenyliodide substitution on myocardial uptake and retention properties, several new Te fatty acids have been synthesized and studied in rats. The new agents were prepared by coupling of internal alkenyl iodides prepared from the corresponding boronic acid analogues with sodium alkoxycarbonyl tellurols. Evaluation of the four new analogues demonstrated an unexpected relationship between chain length, and the position of the Te heteroatom and alkenyliodide moiety. 5 figs., 1 tab.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5977304
• Report Number(s): ORNL/TM-10441; ON: DE88000024
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703 -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550501 -- Metabolism-- Tracer Techniques
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHEMICAL PREPARATION
CHEMICAL REACTIONS
CHEMISTRY
CHROMATOGRAPHY
CLEARANCE
COPPER 64
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVALUATION
EVEN-ODD NUCLEI
HALOGENATION
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINATION
IODINE 125
IODINE 131
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MAMMALS
METABOLITES
MINUTES LIVING RADIOISOTOPES
MONOCARBOXYLIC ACIDS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OSMIUM 191
OSMIUM ISOTOPES
PERFUSED ORGANS
POLARIZATION
PRODUCTION
RADIOCHEMISTRY
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RODENTS
SEPARATION PROCESSES
SYNTHESIS
TELLURIUM COMPOUNDS
THIN-LAYER CHROMATOGRAPHY
VERTEBRATES