Radioiodinated methyl-branched fatty acids: Evaluation of catabolites formed in vivo
Conference
·
OSTI ID:7163868
Radioiodinated terminal iodophenyl-substituted long-chain fatty acids containing either racemic mono-methyl or geminal dimethyl-branching in the alkyl chain have been shown to exhibit delayed myocardial clearance properties which make these agents useful for the SPECT evaluation of myocardial fatty acid uptake patterns. Although the myocardial clearance rate of 15-(p-iodophenyl)-3-R,S- methylpentadecanoic acid (BMIPP) is considerably delayed, in comparison with the IPPA straight-chain analogue, analysis of the radioiodinated lipids present in the outflow tract of isolated rat hearts administered BMIPP have clearly demonstrated the presence of a polar metabolite. The synthesis of ..beta..-hydroxy fatty acids has been developed to allow investigation of the possible formation of ..beta..-hydroxy catabolites in vivo. The preparation of ..beta..-hydroxy BMIPP and ..beta..-hydroxy IPPA are described, and the possible significance of their formation in vivo discussed. 4 figs.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 7163868
- Report Number(s):
- CONF-8711198-1; ON: DE88012492
- Country of Publication:
- United States
- Language:
- English
Similar Records
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids
The development of radioiodinated fatty acids for myocardial imaging
The development of radioiodinated fatty acids for myocardial imaging
Journal Article
·
Wed Feb 29 23:00:00 EST 1984
· J. Med. Chem.; (United States)
·
OSTI ID:6847258
The development of radioiodinated fatty acids for myocardial imaging
Conference
·
Tue Jun 01 00:00:00 EDT 1993
·
OSTI ID:10166649
The development of radioiodinated fatty acids for myocardial imaging
Conference
·
Thu Dec 31 23:00:00 EST 1992
·
OSTI ID:7368496
Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703 -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHEMICAL PREPARATION
CHEMICAL REACTIONS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENZYME INHIBITORS
HALOGENATION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINATION
IODINE 123
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MONOCARBOXYLIC ACIDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOISOTOPES
RADIOPHARMACEUTICALS
SYNTHESIS
400703 -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHEMICAL PREPARATION
CHEMICAL REACTIONS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENZYME INHIBITORS
HALOGENATION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINATION
IODINE 123
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MONOCARBOXYLIC ACIDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOISOTOPES
RADIOPHARMACEUTICALS
SYNTHESIS