Nuclear medicine progress report for quarter ending June 30, 1984

Technical Report · Mon Oct 01 04:00:00 EDT 1984

OSTI ID:6448515

Knapp, Jr, F F; Ambrose, K R; Goodman, M M; Srivastava, P C

Because of the importance of using iodine-123-labeled structurally modified fatty acids for the evaluation of regional differences in myocardial fatty acid uptake to various types of disease, a detailed comparison of the relative myocardial uptake and retention in rats of two model, methyl-branched fatty acids in comparison to the unbranched analogues was evaluated in fasted and unfasted rats. 15-((/sup 123/I)iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) and 15-((/sup 125/I)iodophenyl)pentadecanoic acid (IPP) were combined and administered to groups of fasted and unfasted rats. Rats were sacrificed and the tissue distribution of radioactivity evaluated at several time intervals from 2 min to 2 h. In the same manner, 19-(/sup 123/I)iodo-3-(R,S)-methyl-18-nonadecenoic acid (BMIVN) and 19-(/sup 125/I)iodo-18-nonadecenoic acid (INN) were evaluated in groups of fasted and unfasted rats. These results showed that in unfasted rats the relative heart myocardial clearance and blood levels of the methyl-branched and unbranched fatty acids were similar. In contrast, in fasted rats the straight chain analogues showed a rapid myocardial washout, while the branched analogue showed much longer retention. The subcellular distribution of these radiolabeled fatty acids in heart homogenates obtained after intravenous administration to rats was also evaluated. Under non-fasting conditions the distribution profiles in microsomes, mitochondria and cycloplain were similar. Under fasting conditions, however, there was a shift of the subcellular distribution profile for the straight chain analogue and with a relative amount of radioactivity from the mitochondrial and microsomal fractions. 4 references, 10 figures.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 6448515
• Report Number(s): ORNL/TM-9343; ON: DE85000170
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
DATA
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL DATA
HEART
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MUSCLES
MYOCARDIUM
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RATS
RETENTION
RODENTS
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES