Synthesis and biological evaluation of (E)-19-iodo-3,3-dimethyl-18-nonadecenoic acid, a new dimethyl-branched long-chain fatty acid to evaluate regional myocardial fatty acid uptake

Conference · Wed Jan 01 00:00:00 EST 1986

OSTI ID:5806101

Goodman, M M; Ambrose, K R; Neff, K H; Knapp, Jr, F F

The synthetic method for the preparation of (E)-19-iodo-3,3-dimethyl-18-nonadecenoic acid (DMIVN) involved introduction of substituents into the 2- and 5-positions of a thiophene ring followed by sulfur extrusion of a 2,5-dialkyl thiophene derivative to provide a key 3,3-dimethyl-branched fatty acid intermediate, 17-iodo-3,3-dimethylheptadecanoic acid. Myocardial subcellular distribution studies of the /sup 125/I-labeled DMIVN in fasted rats showed a higher association of radioactivity with the microsomes when compared to the results obtained with the 19-carbon straight chain analogue. With the nonfasted rats the distribution profiles of the two analogues showed differences that seemed to correlate with the differences in myocardial retention that fasting and feeding can induce. 5 refs., 3 figs., 2 tabs.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5806101
• Report Number(s): CONF-8606111-1; ON: DE86009461
• Resource Relation: Conference: 6. international symposium on radiopharmaceutical chemistry, Boston, MA, USA, 29 Jun 1986
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
MONOCARBOXYLIC ACIDS
LABELLING
SUBCELLULAR DISTRIBUTION
TISSUE DISTRIBUTION
CHEMICAL PREPARATION
EXPERIMENTAL DATA
IODINE 123
MYOCARDIUM
ORGANIC IODINE COMPOUNDS
RATS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
DATA
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
HEART
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
MUSCLES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RADIOISOTOPES
RODENTS
SYNTHESIS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550501 - Metabolism- Tracer Techniques