Nuclear medicine progress report for quarter ending December 31, 1985

Technical Report · Thu May 01 04:00:00 EDT 1986

DOI:https://doi.org/10.2172/5620053· OSTI ID:5620053

Knapp, Jr., F. F.; Ambrose, K. R.; Goodman, M. M.; Srivastava, P. C.

The first clinical results with the new iodine-123-labeled methylbranched fatty acid, 15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP), are described in this report. A series of 19 patients were evaluated with (I-123)BMIPP by planar imaging studies. The groups consisted of patients with normal coronary arteries, and patients with single-, double-, and triple-vessel disease. The goal of these studies was to evaluate (I-123)BMIPP for the first time in patients, to analyze regional uptake and wash-out properties, and to compare the results of BMIPP with the straight-chain analogue, (I-123)IPP. The results of wash-out kinetic measurements are described in this report. An important finding was that, in addition to good myocardial images, abnormal (reduced) elimination was observed in patients with coronary artery disease (CAD) which is not observed with other agents such as IPP. Thus, the additional information obtained with BMIPP may be of useful prognostic value. The results of methyl-branching on the subcellular distribution and incorporation into lipid pools of rat hearts using analogues of 19-iodo-18-nonadecenoic acid are also described in this report. 15 figs., 3 tabs.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5620053
• Report Number(s): ORNL/TM-9937; ON: DE86011345
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
COPPER 64
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE 123
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MINUTES LIVING RADIOISOTOPES
MONOCARBOXYLIC ACIDS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OSMIUM 191
OSMIUM ISOTOPES
PATIENTS
PLATINUM 195
PLATINUM ISOTOPES
RADIOISOTOPES
RADIOPHARMACEUTICALS
STABLE ISOTOPES
SUBCELLULAR DISTRIBUTION
USES