Differences in the relative myocardial/organ ratios of iodine-123-BMIPP and the dimethyl-substituted iodine 123-DMIPP fatty acid analogue in humans
Journal Article
·
· Journal of Nuclear Medicine
OSTI ID:563346
- Free Univ. Hospital, Amsterdam (Netherlands); and others
Radioiodinated fatty acid analogues, modified by methyl-substitution are used for SPECT imaging of the heart. The effect of mono- and dimethyl-substitution on biodistribution was investigated in humans to evaluate their relative merits for SPECT image quality. Planar total body scans were performed in fasting patients with coronary artery disease, but without heart failure, one hour after administration of 111 MBq 15-(p-[I-123]-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP, n=7) or III MBq 15-(p-[I-123]-iodophenyl)-3,3-dimethylpentaderanoic acid (DMIPP, n=4). Because these branched fatty acids are used for cardiac imaging, we focussed on heart/organ ratios, by comparing small roi-counts in heart, liver, lung, muscle (thigh) and bladder. Statistical analysis: t-test for unpaired data. Both tracers showed good visualization of the heart. While DMIPP showed a relatively high liver uptake, increased background, ie lung, activity was found for BMIPP. In contrast to DMIPP, BMIPP also showed elevated activity in the bladder.
- OSTI ID:
- 563346
- Report Number(s):
- CONF-970602--
- Journal Information:
- Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: Suppl.5 Vol. 38; ISSN 0161-5505; ISSN JNMEAQ
- Country of Publication:
- United States
- Language:
- English
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Fri Oct 01 00:00:00 EDT 1993
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OSTI ID:10103304