Nuclear medicine progress report for quarter ending December 31, 1985
The first clinical results with the new iodine-123-labeled methylbranched fatty acid, 15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP), are described in this report. A series of 19 patients were evaluated with (I-123)BMIPP by planar imaging studies. The groups consisted of patients with normal coronary arteries, and patients with single-, double-, and triple-vessel disease. The goal of these studies was to evaluate (I-123)BMIPP for the first time in patients, to analyze regional uptake and wash-out properties, and to compare the results of BMIPP with the straight-chain analogue, (I-123)IPP. The results of wash-out kinetic measurements are described in this report. An important finding was that, in addition to good myocardial images, abnormal (reduced) elimination was observed in patients with coronary artery disease (CAD) which is not observed with other agents such as IPP. Thus, the additional information obtained with BMIPP may be of useful prognostic value. The results of methyl-branching on the subcellular distribution and incorporation into lipid pools of rat hearts using analogues of 19-iodo-18-nonadecenoic acid are also described in this report. 15 figs., 3 tabs.
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 5620053
- Report Number(s):
- ORNL/TM-9937; ON: DE86011345
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products. Original copy available until stock is exhausted
- Country of Publication:
- United States
- Language:
- English
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MONOCARBOXYLIC ACIDS
DIAGNOSTIC USES
RADIOPHARMACEUTICALS
SUBCELLULAR DISTRIBUTION
COPPER 64
HEART
IODINE 123
OSMIUM 191
PATIENTS
PLATINUM 195
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OSMIUM ISOTOPES
PLATINUM ISOTOPES
RADIOISOTOPES
STABLE ISOTOPES
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics