Modified cellulose synthase gene from Arabidopsis thaliana confers herbicide resistance to plants
- Portola Valley, CA
- Golm, DE
Cellulose synthase ("CS"), a key enzyme in the biosynthesis of cellulose in plants is inhibited by herbicides comprising thiazolidinones such as 5-tert-butyl-carbamoyloxy-3-(3-trifluromethyl)phenyl-4-thiazolidinone (TZ), isoxaben and 2,6-dichlorobenzonitrile (DCB). Two mutant genes encoding isoxaben and TZ-resistant cellulose synthase have been isolated from isoxaben and TZ-resistant Arabidopsis thaliana mutants. When compared with the gene coding for isoxaben or TZ-sensitive cellulose synthase, one of the resistant CS genes contains a point mutation, wherein glycine residue 998 is replaced by an aspartic acid. The other resistant mutation is due to a threonine to isoleucine change at amino acid residue 942. The mutant CS gene can be used to impart herbicide resistance to a plant; thereby permitting the utilization of the herbicide as a single application at a concentration which ensures the complete or substantially complete killing of weeds, while leaving the transgenic crop plant essentially undamaged.
- Research Organization:
- Carnegie Institute of Washington
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG02-94ER20133
- Assignee:
- U.S. Department of Energy (Washington, DC)
- Patent Number(s):
- 7,241,878
- Application Number:
- 10/721,996
- OSTI ID:
- 912868
- Country of Publication:
- United States
- Language:
- English
A Second Locus, Ixr B1 in Arabidopsis thaliana, that Confers Resistance to the Herbicide Isoxaben
|
journal | March 1990 |
Modifications of cellulose synthase confer resistance to isoxaben and thiazolidinone herbicides in Arabidopsis Ixr1 mutants
|
journal | August 2001 |
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