Boronated porphyrin compounds

Kahl, Stephen B; Koo, Myoung-Seo

Title: Boronated porphyrin compounds

Patent · Wed Jan 01 00:00:00 EST 1992

OSTI ID:868475

Kahl, Stephen B ^[1]; Koo, Myoung-Seo ^[2]

Portola Valley, CA
San Francisco, CA

A compound is described having the structure ##STR1## where R preferably is ##STR2## and most preferably R.sup.3 is a closo-carborane and R.sup.2 is --H, an alkyl or aryl having 1 to about 7 carbon atoms, This invention was made with Government support under NIH Grant No. CA-37961 awarded by the Department of Health and Human Services and under the Associated Universities Inc. Contract No. De-AC02-76CH00016 with the U.S. Department of Energy. The Government has rights in this invention.

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Research Organization:: Associated Universities, Inc., Upton, NY (United States)

DOE Contract Number:: AC02-76CH00016

Assignee:: Regents of University of California (Oakland, CA)

Patent Number(s):: US 5149801

OSTI ID:: 868475

Country of Publication:: United States

Language:: English

References (8)

Boron Neutron Capture Therapy for Cancer Barth, Rolf F.; Soloway, Albert H.; Fairchild, Ralph G. Scientific American, Vol. 263, Issue 4 https://doi.org/10.1038/scientificamerican1090-100	journal	October 1990
Protein-binding polyhedral boranes. 1 Sneath, R. L.; Soloway, A. H.; Dey, A. S. Journal of Medicinal Chemistry, Vol. 17, Issue 8 https://doi.org/10.1021/jm00254a003	journal	August 1974
Optimization of Boron and Neutron Delivery for Neutron Capture Therapy Fairchild, R. G.; Slatkin, D. N.; Coderre, J. A. Pigment Cell Research, Vol. 2, Issue 4 https://doi.org/10.1111/j.1600-0749.1989.tb00210.x	journal	July 1989
Boron hydride derivatives for neutron capture therapy. Antibody approach Wong, Hou S.; Tolpin, Eugene I.; Lipscomb, William N. Journal of Medicinal Chemistry, Vol. 17, Issue 8 https://doi.org/10.1021/jm00254a001	journal	August 1974
Preparation of carboranyl porphyrins for boron neutron capture therapy Miura, Michiko; Gabel, Detlef; Oenbrink, Georg Tetrahedron Letters, Vol. 31, Issue 16 https://doi.org/10.1016/0040-4039(90)80197-T	journal	January 1990
Treatment of Malignant Melanoma by Single Thermal Neutron Capture Therapy with Melanoma-Seeking 10b-Compound Mishima, Yutaka; Honda, Chihiro; Ichihashi, Masamitsu The Lancet, Vol. 334, Issue 8659 https://doi.org/10.1016/S0140-6736(89)90567-9	journal	August 1989
Preparation of tumor-specific boron compounds. 1. In vitro studies using boron-labeled antibodies and elemental boron as neutron targets Hawthorne, M. Frederick; Wiersema, Richard J.; Takasugi, Mitsuo Journal of Medicinal Chemistry, Vol. 15, Issue 5 https://doi.org/10.1021/jm00275a001	journal	May 1972
Distribution of 10B after infusion of Na210B12H11SH into a patient with malignant astrocytoma: implications for boron neutron capture therapy Finkel, G. C.; Poletti, C. E.; Fairchild, R. G. Neurosurgery, Vol. 24, Issue 1 https://doi.org/10.1097/00006123-198901000-00002	journal	January 1989

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boronated
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structure
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preferably
str2
closo-carborane
-h
alkyl
aryl
carbon
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government
support
nih
grant
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department
health
human
services
associated
universities
contract
de-ac02-76ch00016
energy
rights
carbon atoms
carbon atom
government support
associated universities
human services
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Title: Boronated porphyrin compounds

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