Radiopharmaceutical composition containing tantalum-178 and process therefor

Patent · Tue May 16 00:00:00 EDT 1989

OSTI ID:866963

Neirinckx, Rudi D ^[1]; Holman, B Leonard ^[2]; Davis, Michael A ^[3]; Harris, Gale I ^[4]

---

1. Medfield, MA
2. Chestnut Hill, MA
3. Westwood, MA
4. East Lansing, MI

A physiologically acceptable solution of tantalum-178 having an activity of 0.1 to 200 millicuries per milliliter of tantalum-178 solution is provided. The solution is obtained from tungsten-178 bound to a column of an anion exchange resin which forms tantalum-178 in situ by eluting the column with a hydrochloric acid solution containing hydrogen peroxide to form an acidic solution of tantalum-178. The acidic solution of tantalum-178 then is neutralized.

• Research Organization: Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
• DOE Contract Number: AC02-76EV04115
• Assignee: Massachusetts Institute of Technology (Cambridge, MA)
• Patent Number(s): US 4830848
• Application Number: 07/027,573
• OSTI ID: 866963
• Country of Publication: United States
• Language: English

Related Subjects

radiopharmaceutical
composition
containing
tantalum-178
process
physiologically
acceptable
solution
activity
200
millicuries
milliliter
provided
obtained
tungsten-178
bound
column
anion
exchange
resin
forms
situ
eluting
hydrochloric
acid
hydrogen
peroxide
form
acidic
neutralized
containing hydrogen
hydrogen peroxide
hydrochloric acid
anion exchange
acid solution
solution containing
exchange resin
composition containing
acidic solution
radiopharmaceutical composition
pharmaceutical composition
acceptable solution
physiologically acceptable
/424/206/252/