Tantalum-178 - a short-lived nuclide for nuclear medicine: development of a potential generator system

Journal Article · Mon May 01 04:00:00 EDT 1978 · J. Nucl. Med.; (United States)

OSTI ID:6548983

Neirinckx, R D; Jones, A G; Davis, M A; Harris, G I; Holman, B L

We describe a chemical separation that may form the basis of a generator system for the short-lived radionuclide Ta-178 (T/sub 1/2/ = 9 min). The parent nuclide W-178 (T/sub 1/2/ = 21.7 days) is loaded on an anion-exchange column and the daughter eluted with a mixture of dilute hydrochloric acid and hydrogen peroxide. The yields of tantalum and the breakthrough of the tungsten parent as a function of the eluting conditions are discussed, and preliminary animal distribution data are presented for various treatments of the eluant solution.

• Research Organization: Harvard Medical School, Boston, MA
• OSTI ID: 6548983
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 19:5; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400203 -- Isotope Exchange & Isotope Separation-- (-1987)
400703 -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
CHROMATOGRAPHY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-EVEN NUCLEI
HEART
HOURS LIVING RADIOISOTOPES
HYDROCHLORIC ACID
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
INJECTION
INORGANIC ACIDS
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ION EXCHANGE CHROMATOGRAPHY
ISOTOPE PRODUCTION
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
OXYGEN COMPOUNDS
PEROXIDES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RATS
RODENTS
SCINTISCANNING
SEPARATION PROCESSES
TANTALUM 178
TANTALUM ISOTOPES
TISSUE DISTRIBUTION
TUNGSTEN 178
TUNGSTEN ISOTOPES
VERTEBRATES