Instantaneous radioiodination of rose bengal at room temperature and a cold kit therefor

Patent · Thu Jan 01 00:00:00 EST 1981

OSTI ID:864036

Hupf, Homer B ^[1]; Wanek, Philip M ^[2]

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1. Sausolito, CA
2. Los Alamos, NM

The disclosure relates to the radioiodination of rose bengal at room temperature and a cold-kit therefor. A purified rose bengal tablet is stirred into acidified ethanol at or near room temperature, until a suspension forms. Reductant-free .sup.125 I.sup.- is added and the resulting mixture stands until the exchange label reaction occurs at room temperature. A solution of sterile isotonic phosphate buffer and sodium hydroxide is added and the final resulting mixture is sterilized by filtration.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 4298591
• OSTI ID: 864036
• Country of Publication: United States
• Language: English

Related Subjects

instantaneous
radioiodination
rose
bengal
temperature
cold
kit
disclosure
relates
cold-kit
purified
tablet
stirred
acidified
ethanol
near
suspension
forms
reductant-free
125
added
resulting
mixture
stands
exchange
label
reaction
occurs
solution
sterile
isotonic
phosphate
buffer
sodium
hydroxide
final
sterilized
filtration
sodium hydroxide
resulting mixture
disclosure relates
reaction occurs
rose bengal
reaction occur
/424/422/999/