Rapid radioiodination of rose bengal at room temperature

Journal Article · Mon May 01 00:00:00 EDT 1978 · J. Nucl. Med.; (United States)

OSTI ID:5522846

Hupf, H B; Wanek, P M; O'Brien, Jr, H A; Holland, L M

Published methods for radioiodination of rose bengal require reaction times of 1 hr or more at temperature from 50 to 120/sup 0/C. Through the use of an acidified ethanol solvent and potassium iodate oxidant, purified rose bengal is radioiodinated at room temperature within 15 min with chemical yields ranging between 93 and 97%. Radiochemical impurities are sufficiently minimized to permit preparation in a single 10-ml serum vial, requiring no additional purification steps. The method reported here is readily adaptable to cold-kit preparation.

• Research Organization: Los Alamos Scientific Lab., NM
• OSTI ID: 5522846
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 19:5; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400103 -- Radiometric & Radiochemical Procedures-- (-1987)
400105* -- Separation Procedures
400203 -- Isotope Exchange & Isotope Separation-- (-1987)
ALKALI METAL COMPOUNDS
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
DYES
ELEMENTS
HALIDES
HALOGEN COMPOUNDS
HALOGENATION
HALOGENS
HYDROXY ACIDS
INDICATORS
INORGANIC PHOSPHORS
IODIDES
IODINATION
IODINE
IODINE COMPOUNDS
ISOTOPES
LABELLING
NONMETALS
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
PHOSPHORS
POTASSIUM COMPOUNDS
POTASSIUM IODIDES
RADIOISOTOPES
REAGENTS
ROSE BENGAL