Instantaneous radioiodination of rose bengal at room temperature and a cold kit therefor

Patent · Wed Dec 31 23:00:00 EST 1980

OSTI ID:864036

Hupf, Homer B ^[1]; Wanek, Philip M ^[2]

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1. Sausolito, CA
2. Los Alamos, NM

The disclosure relates to the radioiodination of rose bengal at room temperature and a cold-kit therefor. A purified rose bengal tablet is stirred into acidified ethanol at or near room temperature, until a suspension forms. Reductant-free .sup.125 I.sup.- is added and the resulting mixture stands until the exchange label reaction occurs at room temperature. A solution of sterile isotonic phosphate buffer and sodium hydroxide is added and the final resulting mixture is sterilized by filtration.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 4298591
• OSTI ID: 864036
• Country of Publication: United States
• Language: English

Related Subjects

/424/422/999/
125
acidified
added
bengal
buffer
cold
cold-kit
disclosure
disclosure relates
ethanol
exchange
filtration
final
forms
hydroxide
instantaneous
isotonic
kit
label
mixture
near
occurs
phosphate
purified
radioiodination
reaction
reaction occur
reaction occurs
reductant-free
relates
resulting
resulting mixture
rose
rose bengal
sodium
sodium hydroxide
solution
stands
sterile
sterilized
stirred
suspension
tablet
temperature