Nuclear medicine progress report for quarter ending June 30, 1987
The performance of two tungsten-188/rhenium-188 (W-188/Re-188) radionuclide generator systems utilizing either alumina (Al/sub 2/O/sub 3/) eluted with physiological saline or hydrated zirconium oxide (HZO) eluted with methyl ethyl ketone are described. Because of its emission of high-energy ..beta../sup -/ and availability from a reactor-produced parent (W-188) with a long (T/sub 1/2/ 69 days) half-life, Re-188 is an excellent candidate for various therapeutic applications. Both systems gave reproducible daily yields over several weeks with very low W-188 parent breakthrough. The production of W-188 in the High Flux Isotope Reactor (HFIR) was evaluated, and a one cycle irradiation (21 d) of enriched W-186 gave W-188 with a specific activity of 3.5 mCi/mg W-186. The results demonstrate that W-188/Re-188 generators with reproducible performance, long shelf-life and high yields of Re-188 can be prepared from both HZO and Al/sub 2/O/sub 3/. The isolation of a polar catabolite from isolated Langendorff-perfused rat hearts administered the radioiodinated 3-methyl-branched fatty acid, 15-(p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP), is described. This is the first demonstration of the identification of the release of an apparent metabolite associated with the myocardial clearance of BMIPP and suggests that the formation of such a catabolite may occur in vivo. 12 refs., 5 figs.
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 5735181
- Report Number(s):
- ORNL/TM-10531; ON: DE88004766
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products. Original copy available until stock is exhausted
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
RHENIUM 188
PRODUCTION
THERAPEUTIC USES
TUNGSTEN 188
ALUMINIUM OXIDES
FLOWSHEETS
GAMMA DOSIMETRY
HEART
HFIR REACTOR
METABOLITES
NUCLEAR MEDICINE
PROGRESS REPORT
RADIOBIOLOGY
RADIOISOTOPE GENERATORS
RADIOPHARMACEUTICALS
RATS
ZIRCONIUM OXIDES
ALUMINIUM COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGY
BODY
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
DAYS LIVING RADIOISOTOPES
DIAGRAMS
DOCUMENT TYPES
DOSIMETRY
DRUGS
ENRICHED URANIUM REACTORS
EVEN-EVEN NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION REACTORS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE PRODUCTION REACTORS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIOISOTOPES
REACTORS
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
RHENIUM ISOTOPES
RODENTS
TANK TYPE REACTORS
TEST REACTORS
THERMAL REACTORS
TRANSITION ELEMENT COMPOUNDS
TUNGSTEN ISOTOPES
USES
VERTEBRATES
WATER COOLED REACTORS
WATER MODERATED REACTORS
ZIRCONIUM COMPOUNDS
400703* - Radiochemistry & Nuclear Chemistry- Radioisotope Production
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)