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Title: Silicon electronics on silk as a path to bioresorbable, implantable devices

Journal Article · · Applied Physics Letters
DOI:https://doi.org/10.1063/1.3238552· OSTI ID:1876186
 [1];  [1];  [2];  [2];  [2];  [2];  [3];  [1]
  1. Univ. of Illinois at Urbana-Champaign, IL (United States)
  2. Tufts Univ., Medford, MA (United States)
  3. Defense Advanced Research Projects Agency, Arlington, VA (United States)

Many existing and envisioned classes of implantable biomedical devices require high performance electronics/sensors. An approach that avoids some of the longer term challenges in biocompatibility involves a construction in which some parts or all of the system resorbs in the body over time. Furthermore, this paper describes strategies for integrating single crystalline silicon electronics, where the silicon is in the form of nanomembranes, onto water soluble and biocompatible silk substrates. Electrical, bending, water dissolution, and animal toxicity studies suggest that this approach might provide many opportunities for future biomedical devices and clinical applications.

Research Organization:
Univ. of Illinois at Urbana-Champaign, IL (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division; U.S. Army Research Laboratory; US Army Research Office (ARO)
Grant/Contract Number:
FG02-07ER46471; FG02-07ER46453; W911 NF-07–1-0618
OSTI ID:
1876186
Journal Information:
Applied Physics Letters, Vol. 95, Issue 13; ISSN 0003-6951
Publisher:
American Institute of Physics (AIP)Copyright Statement
Country of Publication:
United States
Language:
English

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Neural responses to electrical stimulation on patterned silk films: Electrical Stimulation on Patterned Silk Films journal July 2013
Woven Electrochemical Transistors on Silk Fibers journal December 2010
Advanced Soft Materials, Sensor Integrations, and Applications of Wearable Flexible Hybrid Electronics in Healthcare, Energy, and Environment journal July 2019
Controllably degradable transient electronic antennas based on water-soluble PVA/TiO2 films journal October 2017
Self-deployable current sources fabricated from edible materials journal January 2013
Nanowire transistor arrays for mapping neural circuits in acute brain slices. text January 2010
Metamaterial Silk Composites at Terahertz Frequencies journal July 2010
Biodegradable electronics: cornerstone for sustainable electronics and transient applications journal January 2016
Silk: A Promising Biomaterial Opening New Vistas Towards Affordable Healthcare Solutions journal August 2019
Direct Transfer of Subwavelength Plasmonic Nanostructures on Bioactive Silk Films journal September 2012
Organic Thin-Film Transistors Fabricated on Resorbable Biomaterial Substrates journal February 2010
Hybrid Integrated Label-Free Chemical and Biological Sensors journal March 2014
Fully Printed Light‐Emitting Electrochemical Cells Utilizing Biocompatible Materials journal December 2017
Dissolvable tattoo sensors: from science fiction to a viable technology journal November 2016
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New Opportunities for an Ancient Material journal July 2010
A Natural Silk Fibroin Protein-Based Transparent Bio-Memristor journal July 2012
High-Performance Biodegradable/Transient Electronics on Biodegradable Polymers journal April 2014
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Conducting Polymer-Based Composite Materials for Therapeutic Implantations: From Advanced Drug Delivery System to Minimally Invasive Electronics journal February 2020
Spider silk inspired materials and sustainability: perspective journal July 2015
Advances and challenges of green materials for electronics and energy storage applications: from design to end-of-life recovery journal January 2018
Materials for Bioresorbable Radio Frequency Electronics journal May 2013
Flammable carbon nanotube transistors on a nitrocellulose paper substrate for transient electronics journal September 2016
A Stretchable and Flexible Cardiac Tissue–Electronics Hybrid Enabling Multiple Drug Release, Sensing, and Stimulation journal February 2019
Programing Performance of Wool Keratin and Silk Fibroin Composite Materials by Mesoscopic Molecular Network Reconstruction journal August 2016
A bilayered PVA/PLGA-bioresorbable shuttle to improve the implantation of flexible neural probes. text January 2018
A Silk Fibroin Bio-Transient Solution Processable Memristor journal November 2017
Thermally Triggered Mechanically Destructive Electronics Based On Electrospun Poly(ε-caprolactone) Nanofibrous Polymer Films journal April 2017
Dissolution Behaviors and Applications of Silicon Oxides and Nitrides in Transient Electronics journal April 2014
Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics journal April 2010
Sericin for Resistance Switching Device with Multilevel Nonvolatile Memory journal July 2013
Silk Fibroin for Flexible Electronic Devices journal December 2015
Physically Transient Threshold Switching Device Based on Magnesium Oxide for Security Application journal May 2018
Implantable Devices: Issues and Challenges journal December 2012
Transient Light Emitting Devices Based on Soluble Polymer Composites journal April 2018
Multiscale Soft–Hard Interface Design for Flexible Hybrid Electronics journal August 2019
Materials and Fabrication Processes for Transient and Bioresorbable High-Performance Electronics journal April 2013
Integration of Biomaterials into Sensors Based on Organic Thin-Film Transistors journal May 2018
Materials for Programmed, Functional Transformation in Transient Electronic Systems journal October 2014
Synthesis and characterization of biocompatible nanodiamond-silk hybrid material journal January 2014
Engineering the Future of Silk Materials through Advanced Manufacturing journal June 2018
Biocompatible and Biodegradable Materials for Organic Field-Effect Transistors journal September 2010
Graphene-based wireless bacteria detection on tooth enamel journal January 2012
Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems journal January 2020
Flexible Organic Thin-Film Transistors with Silk Fibroin as the Gate Dielectric journal March 2011
Exploring the Potential of Nucleic Acid Bases in Organic Light Emitting Diodes journal December 2014
Film-Based Implants for Supporting Neuron-Electrode Integrated Interfaces for The Brain journal November 2013
Tissue–electronics interfaces: from implantable devices to engineered tissues journal November 2017
Group IV Nanoparticles: Synthesis, Properties, and Biological Applications journal August 2010
Advances in Materials for Recent Low-Profile Implantable Bioelectronics journal March 2018
Effect of different fabrication methods on the chemo-physical properties of silk fibroin films and on their interaction with neural cells journal January 2016
Physical and chemical aspects of stabilization of compounds in silk journal January 2012
Morphology control for tunable optical properties of cellulose nanofibrils films journal August 2018
25th Anniversary Article: Materials for High-Performance Biodegradable Semiconductor Devices journal February 2014
Materials for stretchable electronics journal March 2012
Biodegradable and biocompatible polymers for electronic applications: A review journal November 2018
Inorganic dissolvable electronics: materials and devices for biomedicine and environment journal August 2016
Liquid crystal models of biological materials and processes journal January 2010
New insights and perspectives into biological materials for flexible electronics journal January 2017
Moisture-triggered physically transient electronics journal September 2017
Bioresorbable Electronic Implants: History, Materials, Fabrication, Devices, and Clinical Applications journal April 2019
Stretchable Field-Effect-Transistor Array of Suspended SnO2 Nanowires journal April 2011

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