Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics

McCall, Jordan G.; Kim, Tae-il; Shin, Gunchul; Huang, Xian; Jung, Yei Hwan; Al-Hasani, Ream; Omenetto, Fiorenzo G.; Bruchas, Michael R.; Rogers, John A.

doi:10.1038/nprot.2013.158

Title: Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics

Journal Article · Thu Nov 07 00:00:00 EST 2013 · Nature Protocols

DOI:https://doi.org/10.1038/nprot.2013.158· OSTI ID:1875435

McCall, Jordan G. ^[1]; Kim, Tae-il ^[2]; Shin, Gunchul ^[3]; Huang, Xian ^[3]; Jung, Yei Hwan ^[4]; Al-Hasani, Ream ^[1]; Omenetto, Fiorenzo G. ^[5]; Bruchas, Michael R. ^[1]; Rogers, John A. ^[3]

Washington Univ. School of Medicine, St. Louis, MO (United States)
Sungkyunkwan University (SKKU), Suwon (South Korea); Inst. for Basic Science (IBS), Daejeon (South Korea)
Univ. of Illinois at Urbana-Champaign, IL (United States)
Univ. of Wisconsin, Madison, WI (United States); Univ. of Illinois at Urbana-Champaign, IL (United States)
Tufts Univ., Medford, MA (United States)

The rise of optogenetics provides unique opportunities to advance materials and biomedical engineering, as well as fundamental understanding in neuroscience. This protocol describes the fabrication of optoelectronic devices for studying intact neural systems. Unlike optogenetic approaches that rely on rigid fiber optics tethered to external light sources, these novel devices carry wirelessly powered microscale, inorganic light-emitting diodes (μ-ILEDs) and multimodal sensors inside the brain. Here, we describe the technical procedures for construction of these devices, their corresponding radiofrequency power scavengers and their implementation in vivo for experimental application. In total, the timeline of the procedure, including device fabrication, implantation and preparation to begin in vivo experimentation, can be completed in ~3–8 weeks. Implementation of these devices allows for chronic (tested for up to 6 months) wireless optogenetic manipulation of neural circuitry in animals navigating complex natural or home-cage environments, interacting socially, and experiencing other freely moving behaviors.

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Research Organization:: Univ. of Illinois at Urbana-Champaign, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division; US National Institutes of Health Common Fund; National Institute on Drug Abuse (NIDA); National Institute of Neurological Disorders and Stroke (NINDS); National Institute of Mental Health (NIMH)

Grant/Contract Number:: FG02-07ER46471; FG02-07ER46453; R01DA037152; R00DA025182; R01NS081707; F31MH101956

OSTI ID:: 1875435

Journal Information:: Nature Protocols, Vol. 8, Issue 12; ISSN 1754-2189

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Timing matters: using optogenetics to chronically manipulate neural circuitry and rhythms Sidor, Michelle M.; McClung, Colleen A. Frontiers in Behavioral Neuroscience, Vol. 8 https://doi.org/10.3389/fnbeh.2014.00041	journal	January 2014

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