Wireless optofluidic systems for programmable in vivo pharmacology and optogenetics

Rogers, John A.; Bruchas, Michael Raymond; Jeong, Jaewoong; McCall, Jordan Gary

Wireless optofluidic systems for programmable in vivo pharmacology and optogenetics

Patent · Tue Nov 02 04:00:00 EDT 2021

OSTI ID:1860014

Rogers, John A.; Bruchas, Michael Raymond; Jeong, Jaewoong; McCall, Jordan Gary

Provided are implantable, injectable and/or surface mounted biomedical devices and related methods for interfacing with a target tissue. The devices have a substrate, one or more microfluidic channels embedded in or supported by the substrate and a fluid actuator in operational communication with one or more reservoirs and responsive to a wireless control signal. The components of the device are specially configured and packaged to be ultra-thin and mechanically compliant. In some embodiments, the devices are self-powered and fully implantable. The devices can be shaped to provide injection in a minimally invasive manner, thereby avoiding unnecessary tissue damage and providing a platform for long-term implantation for interfacing with biological tissue.

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Research Organization:: Univ. of Illinois, Urbana-Champaign, IL (United States)

Sponsoring Organization:: USDOE; National Institutes of Health (NIH)

DOE Contract Number:: FG02-07ER46453; FG02-07ER46471

Assignee:: The Board of Trustees of the University of Illinois (Urbana, IL)

Patent Number(s):: 11,160,489

Application Number:: 15/738,043

OSTI ID:: 1860014

Country of Publication:: United States

Language:: English

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Stretchable organic integrated circuits for large-area electronic skin surfaces Sekitani, Tsuyoshi; Someya, Takao MRS Bulletin, Vol. 37, Issue 3, p. 236-245 https://doi.org/10.1557/mrs.2012.42	journal	March 2012
Mechanically adaptive nanocomposites for neural interfacing Capadona, Jeffrey R.; Tyler, Dustin J.; Zorman, Christian A. MRS Bulletin, Vol. 37, Issue 6 https://doi.org/10.1557/mrs.2012.97	journal	June 2012
Material considerations for peripheral nerve interfacing Kim, Young-tae; Romero-Ortega, Mario I. MRS Bulletin, Vol. 37, Issue 6 https://doi.org/10.1557/mrs.2012.99	journal	June 2012
Characterization of various zinc oxide catalysts and their activity in the dehydration-dehydrogenation of isobutanol Saad, Lamia; Riad, Mary Journal of the Serbian Chemical Society, Vol. 73, Issue 10, p. 997-1009 https://doi.org/10.2298/JSC0810997S	journal	January 2008
Biodegradable Metals for Cardiovascular Stent Application: Interests and New Opportunities Moravej, Maryam; Mantovani, Diego International Journal of Molecular Sciences, Vol. 12, Issue 7, p. 4250-4270 https://doi.org/10.3390/ijms12074250	journal	June 2011
Review on Hydrogel-based pH Sensors and Microsensors Richter, Andreas; Paschew, Georgi; Klatt, Stephan Sensors, Vol. 8, Issue 1, p. 561-581 https://doi.org/10.3390/s8010561	journal	January 2008
Metal Oxides and Ion-Exchanging Surfaces as pH Sensors in Liquids: State-of-the-Art and Outlook Kurzweil, Peter Sensors, Vol. 9, Issue 6, p. 4955-4985 https://doi.org/10.3390/s90604955	journal	June 2009
Miniaturized pH Sensors Based on Zinc Oxide Nanotubes/Nanorods Fulati, Alimujiang; Usman Ali, Syed; Riaz, Muhammad Sensors, Vol. 9, Issue 11, p. 8911-8923 https://doi.org/10.3390/s91108911	journal	November 2009
Low-Voltage Zinc-Oxide Thin-Film Transistors on a Conventional SiO2 Gate Insulator Grown by Radio-Frequency Magnetron Sputtering at Room Temperature Jeon, Hoonha; Noh, Kyoungseok; Kim, Do-Hyun Journal of the Korean Physical Society, Vol. 51, Issue 6, p. 1999-2003 https://doi.org/10.3938/jkps.51.1999	journal	December 2007
The effects of rapid thermal annealing on the performance of ZnO thin-film transistors Choi, Duck-Kyun; Park, Chan Jun; Lee, Sung Bo Journal of the Korean Physical Society, Vol. 55, Issue 5(1), p. 1925-1930 https://doi.org/10.3938/jkps.55.1925	journal	November 2009
Ventromedial hypothalamic neurons control a defensive emotion state Kunwar, Prabhat S.; Zelikowsky, Moriel; Remedios, Ryan eLife, Vol. 4 https://doi.org/10.7554/eLife.06633	journal	March 2015

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