Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics

Kim, Tae-il; McCall, Jordan G.; Jung, Yei Hwan; Huang, Xian; Siuda, Edward R.; Li, Yuhang; Song, Jizhou; Song, Young Min; Pao, Hsuan An; Kim, Rak-Hwan; Lu, Chaofeng; Lee, Sung Dan; Song, Il-Sun; Shin, GunChul; Al-Hasani, Ream; Kim, Stanley; Tan, Meng Peun; Huang, Yonggang; Omenetto, Fiorenzo G.; Rogers, John A.; Bruchas, Michael R.

doi:10.1126/science.1232437

Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics

Journal Article · Fri Apr 12 00:00:00 EDT 2013 · Science

DOI:https://doi.org/10.1126/science.1232437· OSTI ID:1875506

Kim, Tae-il ^[1]; McCall, Jordan G. ^[2]; Jung, Yei Hwan ^[3]; Huang, Xian ^[4]; Siuda, Edward R. ^[2]; Li, Yuhang ^[5]; Song, Jizhou ^[6]; Song, Young Min ^[4]; Pao, Hsuan An ^[4]; Kim, Rak-Hwan ^[4]; Lu, Chaofeng ^[7]; Lee, Sung Dan ^[4]; Song, Il-Sun ^[4]; Shin, GunChul ^[4]; Al-Hasani, Ream ^[2]; Kim, Stanley ^[4]; Tan, Meng Peun ^[4]; Huang, Yonggang ^[5]; Omenetto, Fiorenzo G. ^[8]; Rogers, John A. ^[4] more »

Univ. of Illinois at Urbana-Champaign, IL (United States); Sungkyunkwan University (SKKU), Suwon (Korea); University of Illinois
Washington Univ. School of Medicine, St. Louis, MO (United States)
Univ. of Illinois at Urbana-Champaign, IL (United States); Univ. of Wisconsin, Madison, WI (United States)
Univ. of Illinois at Urbana-Champaign, IL (United States)
Northwestern Univ., Evanston, IL (United States)
Univ. of Miami, Coral Gables, FL (United States)
Zhejiang Univ., Hangzhou (China)
Tufts Univ., Medford, MA (United States)

Successful integration of advanced semiconductor devices with biological systems will accelerate basic scientific discoveries and their translation into clinical technologies. In neuroscience generally, and in optogenetics in particular, the ability to insert light sources, detectors, sensors, and other components into precise locations of the deep brain yields versatile and important capabilities. Here, we introduce an injectable class of cellular-scale optoelectronics that offers such features, with examples of unmatched operational modes in optogenetics, including completely wireless and programmed complex behavioral control over freely moving animals. Furthermore, the ability of these ultrathin, mechanically compliant, biocompatible devices to afford minimally invasive operation in the soft tissues of the mammalian brain foreshadow applications in other organ systems, with potential for broad utility in biomedical science and engineering.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of Illinois at Urbana-Champaign, IL (United States)

Sponsoring Organization:: NIH; NIH Common Fund; National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse; USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division

Grant/Contract Number:: FG02-07ER46471

OSTI ID:: 1875506

Journal Information:: Science, Journal Name: Science Journal Issue: 6129 Vol. 340; ISSN 0036-8075

Publisher:: AAASCopyright Statement

Country of Publication:: United States

Language:: English

References (48)

Development and characteristics of a biological tissue-equivalent phantom for microwaves Ito, Koichi; Furuya, Katsumi; Okano, Yoshinobu Electronics and Communications in Japan (Part I: Communications), Vol. 84, Issue 4 https://doi.org/10.1002/1520-6424(200104)84:4<67::AID-ECJA8>3.0.CO;2-D	journal	January 2000
High-Efficiency, Microscale GaN Light-Emitting Diodes and Their Thermal Properties on Unusual Substrates Kim, Tae-il; Jung, Yei Hwan; Song, Jizhou Small, Vol. 8, Issue 11 https://doi.org/10.1002/smll.201200382	journal	March 2012
Brain responses to micro-machined silicon devices Szarowski, D. H.; Andersen, M. D.; Retterer, S. Brain Research, Vol. 983, Issue 1-2 https://doi.org/10.1016/S0006-8993(03)03023-3	journal	September 2003
Insertion shuttle with carboxyl terminated self-assembled monolayer coatings for implanting flexible polymer neural probes in the brain Kozai, Takashi D. Yoshida; Kipke, Daryl R. Journal of Neuroscience Methods, Vol. 184, Issue 2, p. 199-205 https://doi.org/10.1016/j.jneumeth.2009.08.002	journal	November 2009
Embedded benzocyclobutene in silicon: An integrated fabrication process for electrical and thermal isolation in MEMS Modafe, Alireza; Ghalichechian, Nima; Powers, Michael Microelectronic Engineering, Vol. 82, Issue 2 https://doi.org/10.1016/j.mee.2005.07.005	journal	October 2005
Optogenetics in Neural Systems Yizhar, Ofer; Fenno, Lief E.; Davidson, Thomas J. Neuron, Vol. 71, Issue 1 https://doi.org/10.1016/j.neuron.2011.06.004	journal	July 2011
Selective p38α MAPK Deletion in Serotonergic Neurons Produces Stress Resilience in Models of Depression and Addiction Bruchas, Michael R.; Schindler, Abigail G.; Shankar, Haripriya Neuron, Vol. 71, Issue 3 https://doi.org/10.1016/j.neuron.2011.06.011	journal	August 2011
Recombinase-Driver Rat Lines: Tools, Techniques, and Optogenetic Application to Dopamine-Mediated Reinforcement Witten, Ilana B.; Steinberg, Elizabeth E.; Lee, Soo Yeun Neuron, Vol. 72, Issue 5 https://doi.org/10.1016/j.neuron.2011.10.028	journal	December 2011
GABA Neurons of the VTA Drive Conditioned Place Aversion Tan, Kelly R.; Yvon, Cédric; Turiault, Marc Neuron, Vol. 73, Issue 6 https://doi.org/10.1016/j.neuron.2012.02.015	journal	March 2012
Temporally precise in vivo control of intracellular signalling Airan, Raag D.; Thompson, Kimberly R.; Fenno, Lief E. Nature, Vol. 458, Issue 7241 https://doi.org/10.1038/nature07926	journal	March 2009
Amygdala circuitry mediating reversible and bidirectional control of anxiety Tye, Kay M.; Prakash, Rohit; Kim, Sung-Yon Nature, Vol. 471, Issue 7338 https://doi.org/10.1038/nature09820	journal	March 2011
Input-specific control of reward and aversion in the ventral tegmental area Lammel, Stephan; Lim, Byung Kook; Ran, Chen Nature, Vol. 491, Issue 7423 https://doi.org/10.1038/nature11527	journal	October 2012
Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics Kim, Dae-Hyeong; Viventi, Jonathan; Amsden, Jason J. Nature Materials, Vol. 9, Issue 6, p. 511-517 https://doi.org/10.1038/nmat2745	journal	April 2010
Highly sensitive flexible pressure sensors with microstructured rubber dielectric layers Mannsfeld, Stefan C. B.; Tee, Benjamin C-K.; Stoltenberg, Randall M. Nature Materials, Vol. 9, Issue 10, p. 859-864 https://doi.org/10.1038/nmat2834	journal	September 2010
Macroporous nanowire nanoelectronic scaffolds for synthetic tissues Tian, Bozhi; Liu, Jia; Dvir, Tal Nature Materials, Vol. 11, Issue 11, p. 986-994 https://doi.org/10.1038/nmat3404	journal	August 2012
Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins Mattis, Joanna; Tye, Kay M.; Ferenczi, Emily A. Nature Methods, Vol. 9, Issue 2, p. 159-172 https://doi.org/10.1038/nmeth.1808	journal	December 2011
Tuning arousal with optogenetic modulation of locus coeruleus neurons Carter, Matthew E.; Yizhar, Ofer; Chikahisa, Sachiko Nature Neuroscience, Vol. 13, Issue 12 https://doi.org/10.1038/nn.2682	journal	October 2010
Optetrode: a multichannel readout for optogenetic control in freely moving mice Anikeeva, Polina; Andalman, Aaron S.; Witten, Ilana Nature Neuroscience, Vol. 15, Issue 1 https://doi.org/10.1038/nn.2992	journal	December 2011
Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance Stamatakis, Alice M.; Stuber, Garret D. Nature Neuroscience, Vol. 15, Issue 8 https://doi.org/10.1038/nn.3145	journal	June 2012
Specific Role of VTA Dopamine Neuronal Firing Rates and Morphology in the Reversal of Anxiety-Related, but not Depression-Related Behavior in the ClockΔ19 Mouse Model of Mania Coque, Laurent; Mukherjee, Shibani; Cao, Jun-Li Neuropsychopharmacology, Vol. 36, Issue 7 https://doi.org/10.1038/npp.2011.33	journal	March 2011
Construction of implantable optical fibers for long-term optogenetic manipulation of neural circuits Sparta, Dennis R.; Stamatakis, Alice M.; Phillips, Jana L. Nature Protocols, Vol. 7, Issue 1 https://doi.org/10.1038/nprot.2011.413	journal	December 2011
Nanowire transistor arrays for mapping neural circuits in acute brain slices Qing, Quan; Pal, Sumon K.; Tian, Bozhi Proceedings of the National Academy of Sciences, Vol. 107, Issue 5 https://doi.org/10.1073/pnas.0914737107	journal	January 2010
Serine 363 Is Required for Nociceptin/Orphanin FQ Opioid Receptor (NOPR) Desensitization, Internalization, and Arrestin Signaling Zhang, Nancy R.; Planer, William; Siuda, Edward R. Journal of Biological Chemistry, Vol. 287, Issue 50 https://doi.org/10.1074/jbc.M112.405696	journal	December 2012
3D flexible multichannel neural probe array Takeuchi, Shoji; Suzuki, Takafumi; Mabuchi, Kunihiko Journal of Micromechanics and Microengineering, Vol. 14, Issue 1 https://doi.org/10.1088/0960-1317/14/1/014	journal	October 2003
Bio-heat transfer model of deep brain stimulation-induced temperature changes Elwassif, Maged M.; Kong, Qingjun; Vazquez, Maribel Journal of Neural Engineering, Vol. 3, Issue 4 https://doi.org/10.1088/1741-2560/3/4/008	journal	November 2006
An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology Aravanis, Alexander M.; Wang, Li-Ping; Zhang, Feng Journal of Neural Engineering, Vol. 4, Issue 3 https://doi.org/10.1088/1741-2560/4/3/S02	journal	May 2007
Instrumentation for low frequency EIT studies of the human head and its validation in phantom experiments Esler, Brian; Lyons, Thomas; Turovets, Sergei Journal of Physics: Conference Series, Vol. 224 https://doi.org/10.1088/1742-6596/224/1/012007	journal	April 2010
Development of an infrared thermopile detector with a thin self-supporting SU-8 membrane Mattsson, C. G.; Thungstrom, G.; Bertilsson, K. 2007 IEEE Sensors https://doi.org/10.1109/ICSENS.2007.4388531	conference	October 2007
An Integrated μLED Optrode for Optogenetic Stimulation and Electrical Recording Cao, Hung; Gu, Ling; Mohanty, S. K. IEEE Transactions on Biomedical Engineering, Vol. 60, Issue 1 https://doi.org/10.1109/TBME.2012.2217395	journal	January 2013
Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning Tsai, H. -C.; Zhang, F.; Adamantidis, A. Science, Vol. 324, Issue 5930 https://doi.org/10.1126/science.1168878	journal	April 2009
Organic Nonvolatile Memory Transistors for Flexible Sensor Arrays Sekitani, T.; Yokota, T.; Zschieschang, U. Science, Vol. 326, Issue 5959 https://doi.org/10.1126/science.1179963	journal	December 2009
Three-Dimensional, Flexible Nanoscale Field-Effect Transistors as Localized Bioprobes Tian, B.; Cohen-Karni, T.; Qing, Q. Science, Vol. 329, Issue 5993 https://doi.org/10.1126/science.1192033	journal	August 2010
Epidermal Electronics Kim, D.-H.; Lu, N.; Ma, R. Science, Vol. 333, Issue 6044, p. 838-843 https://doi.org/10.1126/science.1206157	journal	August 2011
A Conformal, Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Viventi, J.; Kim, D.-H.; Moss, J. D. Science Translational Medicine, Vol. 2, Issue 24, p. 24ra22-24ra22 https://doi.org/10.1126/scitranslmed.3000738	journal	March 2010
Diode probes for spatiotemporal optical control of multiple neurons in freely moving animals Stark, Eran; Koos, Tibor; Buzsáki, György Journal of Neurophysiology, Vol. 108, Issue 1 https://doi.org/10.1152/jn.00153.2012	journal	July 2012
Nanowire transistor arrays for mapping neural circuits in acute brain slices. Qing, Quan; Pal, Sumon K.; Tian, Bozhi Carnegie Mellon University https://doi.org/10.1184/r1/6096575	text	January 2010
Three-dimensional, flexible nanoscale field-effect transistors as localized bioprobes. Tian, Bozhi; Cohen-Karni, Itzhaq; Qing, Quan Carnegie Mellon University https://doi.org/10.1184/r1/6096938	text	January 2010
Thermal and mechanical analysis of an SU8 polymeric actuator using infrared thermography Solano, B.; Rolt, S.; Wood, D. Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, Vol. 222, Issue 1 https://doi.org/10.1243/09544062JMES676	journal	January 2008
Three-dimensional multiwaveguide probe array for light delivery to distributed brain circuits Zorzos, Anthony N.; Scholvin, Jorg; Boyden, Edward S. Optics Letters, Vol. 37, Issue 23 https://doi.org/10.1364/OL.37.004841	journal	January 2012
Optogenetic Mimicry of the Transient Activation of Dopamine Neurons by Natural Reward Is Sufficient for Operant Reinforcement Kim, Kyung Man; Baratta, Michael V.; Yang, Aimei PLoS ONE, Vol. 7, Issue 4 https://doi.org/10.1371/journal.pone.0033612	journal	April 2012
4 2 Nicotinic Acetylcholine Receptors on Dopaminergic Neurons Mediate Nicotine Reward and Anxiety Relief McGranahan, T. M.; Patzlaff, N. E.; Grady, S. R. Journal of Neuroscience, Vol. 31, Issue 30 https://doi.org/10.1523/JNEUROSCI.0937-11.2011	journal	July 2011
Optogenetic Interrogation of Dopaminergic Modulation of the Multiple Phases of Reward-Seeking Behavior Adamantidis, A. R.; Tsai, H. -C.; Boutrel, B. Journal of Neuroscience, Vol. 31, Issue 30 https://doi.org/10.1523/JNEUROSCI.2246-11.2011	journal	July 2011
Thin films and microelectrode arrays for neuroprosthetics Ordonez, Juan; Schuettler, Martin; Boehler, Christian MRS Bulletin, Vol. 37, Issue 6 https://doi.org/10.1557/mrs.2012.117	journal	June 2012
Stretchable organic integrated circuits for large-area electronic skin surfaces Sekitani, Tsuyoshi; Someya, Takao MRS Bulletin, Vol. 37, Issue 3, p. 236-245 https://doi.org/10.1557/mrs.2012.42	journal	March 2012
Material considerations for peripheral nerve interfacing Kim, Young-tae; Romero-Ortega, Mario I. MRS Bulletin, Vol. 37, Issue 6 https://doi.org/10.1557/mrs.2012.99	journal	June 2012
Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance D., Stuber, Garret; M., Stamatakis, Alice The University of North Carolina at Chapel Hill University Libraries https://doi.org/10.17615/yvan-ej91	text	January 2012
Tuning arousal with optogenetic modulation of locus coeruleus neurons. Carter, Matthew E.; Yizhar, Ofer; Chikahisa, Sachiko Nature America https://doi.org/10.7892/boris.117261	text	January 2010
Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Tsai, Hsing-Chen; Zhang, Feng; Adamantidis, Antoine Roger American Association for the Advancement of Science https://doi.org/10.7892/boris.117268	text	January 2009

Cited By (111)

Thermal management of micro-scale inorganic light-emittng diodes on an orthotropic substrate for biointegrated applications Li, Yuhang; Chen, Jin; Xing, Yufeng Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/s41598-017-06798-5	journal	July 2017
Crack-induced Ag nanowire networks for transparent, stretchable, and highly sensitive strain sensors Lee, Chan-Jae; Park, Keum Hwan; Han, Chul Jong Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/s41598-017-08484-y	journal	August 2017
Cardiac Optogenetics: Enhancement by All-trans-Retinal Yu, Jinzhu; Chen, Kay; Lucero, Rachel V. Scientific Reports, Vol. 5, Issue 1 https://doi.org/10.1038/srep16542	journal	November 2015
Deformable devices with integrated functional nanomaterials for wearable electronics Kim, Jaemin; Lee, Jongsu; Son, Donghee Nano Convergence, Vol. 3, Issue 1 https://doi.org/10.1186/s40580-016-0062-1	journal	March 2016
Pain Inhibition by Optogenetic Activation of Specific Anterior Cingulate Cortical Neurons Gu, Ling; Uhelski, Megan L.; Anand, Sanjay PLOS ONE, Vol. 10, Issue 2 https://doi.org/10.1371/journal.pone.0117746	journal	February 2015
Optogenetics, physiology, and emotions Kravitz, Alexxai V.; Bonci, Antonello Frontiers in Behavioral Neuroscience, Vol. 7 https://doi.org/10.3389/fnbeh.2013.00169	journal	January 2013
Timing matters: using optogenetics to chronically manipulate neural circuitry and rhythms Sidor, Michelle M.; McClung, Colleen A. Frontiers in Behavioral Neuroscience, Vol. 8 https://doi.org/10.3389/fnbeh.2014.00041	journal	January 2014
Optogenetic insights on the relationship between anxiety-related behaviors and social deficits Allsop, Stephen A.; Vander Weele, Caitlin M.; Wichmann, Romy Frontiers in Behavioral Neuroscience, Vol. 8 https://doi.org/10.3389/fnbeh.2014.00241	journal	July 2014
Optogenetic activation of neocortical neurons in vivo with a sapphire-based micro-scale LED probe McAlinden, Niall; Gu, Erdan; Dawson, Martin D. Frontiers in Neural Circuits, Vol. 9 https://doi.org/10.3389/fncir.2015.00025	journal	May 2015
A long-lasting wireless stimulator for small mammals Hentall, Ian D. Frontiers in Neuroengineering https://doi.org/10.3389/fneng.2013.00008	journal	October 2013
Controlling feeding behavior by chemical or gene-directed targeting in the brain: what's so spatial about our methods? Khan, Arshad M. Frontiers in Neuroscience, Vol. 7 https://doi.org/10.3389/fnins.2013.00182	journal	January 2013
Micro- and Nanotechnologies for Optical Neural Interfaces Pisanello, Ferruccio; Sileo, Leonardo; De Vittorio, Massimo Frontiers in Neuroscience, Vol. 10 https://doi.org/10.3389/fnins.2016.00070	journal	March 2016
Freedom of Thought and Mental Integrity: The Moral Requirements for Any Neural Prosthesis Lavazza, Andrea Frontiers in Neuroscience, Vol. 12 https://doi.org/10.3389/fnins.2018.00082	journal	February 2018
A Compact Closed-Loop Optogenetics System Based on Artifact-Free Transparent Graphene Electrodes Liu, Xin; Lu, Yichen; Iseri, Ege Frontiers in Neuroscience, Vol. 12 https://doi.org/10.3389/fnins.2018.00132	journal	March 2018
Microscale Inorganic LED Based Wireless Neural Systems for Chronic in vivo Optogenetics Qazi, Raza; Kim, Choong Yeon; Byun, Sang-Hyuk Frontiers in Neuroscience, Vol. 12 https://doi.org/10.3389/fnins.2018.00764	journal	October 2018
A wirelessly controlled implantable LED system for deep brain optogenetic stimulation Rossi, Mark A.; Go, Vinson; Murphy, Tracy Frontiers in Integrative Neuroscience, Vol. 9 https://doi.org/10.3389/fnint.2015.00008	journal	February 2015
Tools, methods, and applications for optophysiology in neuroscience Smedemark-Margulies, Niklas; Trapani, Josef G. Frontiers in Molecular Neuroscience, Vol. 6, Article No. 18 https://doi.org/10.3389/fnmol.2013.00018	journal	January 2013
Drive the Car(go)s—New Modalities to Control Cargo Trafficking in Live Cells Mondal, Payel; Khamo, John S.; Krishnamurthy, Vishnu V. Frontiers in Molecular Neuroscience, Vol. 10 https://doi.org/10.3389/fnmol.2017.00004	journal	January 2017
Design, fabrication, and packaging of an integrated, wirelessly-powered optrode array for optogenetics application Kwon, Ki Yong; Lee, Hyung-Min; Ghovanloo, Maysam Frontiers in Systems Neuroscience, Vol. 9 https://doi.org/10.3389/fnsys.2015.00069	journal	May 2015
Computer Vision Evidence Supporting Craniometric Alignment of Rat Brain Atlases to Streamline Expert-Guided, First-Order Migration of Hypothalamic Spatial Datasets Related to Behavioral Control Khan, Arshad M.; Perez, Jose G.; Wells, Claire E. Frontiers in Systems Neuroscience, Vol. 12 https://doi.org/10.3389/fnsys.2018.00007	journal	May 2018
Tools for Controlling Activity of Neural Circuits Can Boost Gastrointestinal Research Aviello, Gabriella; D'Agostino, Giuseppe Frontiers in Pharmacology, Vol. 7 https://doi.org/10.3389/fphar.2016.00043	journal	March 2016
Principles of Optogenetic Methods and Their Application to Cardiac Experimental Systems Ferenczi, Emily A.; Tan, Xiaoqiu; Huang, Christopher L. -H. Frontiers in Physiology, Vol. 10 https://doi.org/10.3389/fphys.2019.01096	journal	September 2019
Using Personal Sensors to Assess the Exposome and Acute Health Effects Nieuwenhuijsen, Mark; Donaire-Gonzalez, David; Foraster, Maria International Journal of Environmental Research and Public Health, Vol. 11, Issue 8 https://doi.org/10.3390/ijerph110807805	journal	August 2014
Biocompatible and Implantable Optical Fibers and Waveguides for Biomedicine Nazempour, Roya; Zhang, Qianyi; Fu, Ruxing Materials, Vol. 11, Issue 8 https://doi.org/10.3390/ma11081283	journal	July 2018
Neural Probes for Chronic Applications Kook, Geon; Lee, Sung; Lee, Hee Micromachines, Vol. 7, Issue 10 https://doi.org/10.3390/mi7100179	journal	October 2016
LED Optrode with Integrated Temperature Sensing for Optogenetics Goncalves, S.; Palha, José; Fernandes, Helena Micromachines, Vol. 9, Issue 9 https://doi.org/10.3390/mi9090473	journal	September 2018
Surface/Interface Engineering for Constructing Advanced Nanostructured Photodetectors with Improved Performance: A Brief Review Ding, Meng; Guo, Zhen; Chen, Xuehang Nanomaterials, Vol. 10, Issue 2 https://doi.org/10.3390/nano10020362	journal	February 2020
Process, Design and Materials for Unidirectionally Tilted Polymeric Micro/Nanohairs and Their Adhesion Characteristics Im, Hyeon; Kim, Jong; Han, Sungwon Polymers, Vol. 8, Issue 9 https://doi.org/10.3390/polym8090326	journal	September 2016
Effective Assembly of Nano-Ceramic Materials for High and Anisotropic Thermal Conductivity in a Polymer Composite Hong, Haeleen; Kim, Jong; Kim, Tae-il Polymers, Vol. 9, Issue 12 https://doi.org/10.3390/polym9090413	journal	September 2017
A Wireless Optogenetic Headstage with Multichannel Electrophysiological Recording Capability Gagnon-Turcotte, Gabriel; Kisomi, Alireza; Ameli, Reza Sensors, Vol. 15, Issue 9 https://doi.org/10.3390/s150922776	journal	September 2015
Recent Progress on Non-Conventional Microfabricated Probes for the Chronic Recording of Cortical Neural Activity Kim, Chaebin; Jeong, Joonsoo; Kim, Sung June Sensors, Vol. 19, Issue 5 https://doi.org/10.3390/s19051069	journal	March 2019
Integrating precision medicine in the study and clinical treatment of a severely mentally ill person Oâ€™Rawe, Jason A.; Fang, Han; Rynearson, Shawn PeerJ, Vol. 1 https://doi.org/10.7717/peerj.177	journal	October 2013
A 72 × 60 Angle-Sensitive SPAD Imaging Array for Lens-less FLIM Lee, Changhyuk; Johnson, Ben; Jung, Taesung Columbia University https://doi.org/10.7916/d8nz8hq7	text	January 2016
Polymer Fiber Probes Enable Optical Control of Spinal Cord and Muscle Function In Vivo Lu, Chi; Froriep, Ulrich P.; Koppes, Ryan A. Advanced Functional Materials, Vol. 24, Issue 42 https://doi.org/10.1002/adfm.201401266	journal	August 2014
Stretchable and Transparent Biointerface Using Cell-Sheet-Graphene Hybrid for Electrophysiology and Therapy of Skeletal Muscle Kim, Seok Joo; Cho, Kyoung Won; Cho, Hye Rim Advanced Functional Materials, Vol. 26, Issue 19 https://doi.org/10.1002/adfm.201504578	journal	March 2016
A Materials Roadmap to Functional Neural Interface Design Wellman, Steven M.; Eles, James R.; Ludwig, Kip A. Advanced Functional Materials, Vol. 28, Issue 12 https://doi.org/10.1002/adfm.201701269	journal	July 2017
Transferred, Ultrathin Oxide Bilayers as Biofluid Barriers for Flexible Electronic Implants Song, Enming; Lee, Yoon Kyeung; Li, Rui Advanced Functional Materials, Vol. 28, Issue 12 https://doi.org/10.1002/adfm.201702284	journal	July 2017
Fully Printed Light‐Emitting Electrochemical Cells Utilizing Biocompatible Materials Zimmermann, Johannes; Porcarelli, Luca; Rödlmeier, Tobias Advanced Functional Materials, Vol. 28, Issue 24 https://doi.org/10.1002/adfm.201705795	journal	December 2017
Wet-Responsive, Reconfigurable, and Biocompatible Hydrogel Adhesive Films for Transfer Printing of Nanomembranes Yi, Hoon; Seong, Minho; Sun, Kahyun Advanced Functional Materials, Vol. 28, Issue 18 https://doi.org/10.1002/adfm.201706498	journal	February 2018
Merging Biology and Solid‐State Lighting: Recent Advances in Light‐Emitting Diodes Based on Biological Materials Fresta, Elisa; Fernández‐Luna, Verónica; Coto, Pedro B. Advanced Functional Materials, Vol. 28, Issue 24 https://doi.org/10.1002/adfm.201707011	journal	December 2017
Flexible and Stretchable Smart Display: Materials, Fabrication, Device Design, and System Integration Koo, Ja Hoon; Kim, Dong Chan; Shim, Hyung Joon Advanced Functional Materials, Vol. 28, Issue 35 https://doi.org/10.1002/adfm.201801834	journal	July 2018
Micro Light‐Emitting Diodes for Display and Flexible Biomedical Applications Lee, Han Eol; Shin, Jung Ho; Park, Jung Hwan Advanced Functional Materials, Vol. 29, Issue 24 https://doi.org/10.1002/adfm.201808075	journal	April 2019
Ultrathin Injectable Sensors of Temperature, Thermal Conductivity, and Heat Capacity for Cardiac Ablation Monitoring Koh, Ahyeon; Gutbrod, Sarah R.; Meyers, Jason D. Advanced Healthcare Materials, Vol. 5, Issue 3 https://doi.org/10.1002/adhm.201500451	journal	December 2015
25th Anniversary Article: The Evolution of Electronic Skin (E-Skin): A Brief History, Design Considerations, and Recent Progress Hammock, Mallory L.; Chortos, Alex; Tee, Benjamin C. -K. Advanced Materials, Vol. 25, Issue 42 https://doi.org/10.1002/adma.201302240	journal	October 2013
Recent Advances in Flexible and Stretchable Bio-Electronic Devices Integrated with Nanomaterials Choi, Suji; Lee, Hyunjae; Ghaffari, Roozbeh Advanced Materials, Vol. 28, Issue 22 https://doi.org/10.1002/adma.201504150	journal	January 2016
Flexible GaN Light-Emitting Diodes Using GaN Microdisks Epitaxial Laterally Overgrown on Graphene Dots Chung, Kunook; Yoo, Hyobin; Hyun, Jerome K. Advanced Materials, Vol. 28, Issue 35 https://doi.org/10.1002/adma.201601894	journal	June 2016
Recent Advances in Biointegrated Optoelectronic Devices Xu, Huihua; Yin, Lan; Liu, Chuan Advanced Materials, Vol. 30, Issue 33 https://doi.org/10.1002/adma.201800156	journal	May 2018
Materials and Techniques for Implantable Nutrient Sensing Using Flexible Sensors Integrated with Metal-Organic Frameworks Ling, Wei; Liew, Guoguang; Li, Ya Advanced Materials, Vol. 30, Issue 23 https://doi.org/10.1002/adma.201800917	journal	April 2018
Transient Light‐Emitting Diodes Constructed from Semiconductors and Transparent Conductors that Biodegrade Under Physiological Conditions Lu, Di; Liu, Tzu‐Li; Chang, Jan‐Kai Advanced Materials, Vol. 31, Issue 42 https://doi.org/10.1002/adma.201902739	journal	September 2019
A Removable Insertion Shuttle for Ultraflexible Neural Probe Implantation with Stable Chronic Brain Electrophysiological Recording Zhang, Shun; Wang, Chengjun; Gao, Huan Advanced Materials Interfaces, Vol. 7, Issue 6 https://doi.org/10.1002/admi.201901775	journal	January 2020
Recent Advances in Flexible Inorganic Light Emitting Diodes: From Materials Design to Integrated Optoelectronic Platforms Zhang, Hao; Rogers, John A. Advanced Optical Materials, Vol. 7, Issue 2 https://doi.org/10.1002/adom.201800936	journal	September 2018
Biological Considerations of Optical Interfaces for Neuromodulation Hart, William L.; Kameneva, Tatiana; Wise, Andrew K. Advanced Optical Materials, Vol. 7, Issue 19 https://doi.org/10.1002/adom.201900385	journal	July 2019
Taking Electrons out of Bioelectronics: From Bioprotonic Transistors to Ion Channels Strakosas, Xenofon; Selberg, John; Hemmatian, Zahra Advanced Science, Vol. 4, Issue 7 https://doi.org/10.1002/advs.201600527	journal	March 2017
Thin, Transferred Layers of Silicon Dioxide and Silicon Nitride as Water and Ion Barriers for Implantable Flexible Electronic Systems Song, Enming; Fang, Hui; Jin, Xin Advanced Electronic Materials, Vol. 3, Issue 8 https://doi.org/10.1002/aelm.201700077	journal	June 2017
Microfabricated Probes for Studying Brain Chemistry: A Review Ngernsutivorakul, Thitaphat; White, Thomas S.; Kennedy, Robert T. ChemPhysChem, Vol. 19, Issue 10 https://doi.org/10.1002/cphc.201701180	journal	February 2018
3D electronic and photonic structures as active biological interfaces Wang, Huachun; Sun, Pengcheng; Yin, Lan InfoMat, Vol. 2, Issue 3 https://doi.org/10.1002/inf2.12054	journal	December 2019
Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics Noh, Kyung Nim; Park, Sung Il; Qazi, Raza Small, Vol. 14, Issue 4 https://doi.org/10.1002/smll.201702479	journal	December 2017
Low Threshold Fabry-Pérot Mode Lasing from Lead Iodide Trapezoidal Nanoplatelets Zhong, Yangguang; Wei, Qi; Liu, Zhen Small, Vol. 14, Issue 35 https://doi.org/10.1002/smll.201801938	journal	July 2018
Using Artificial Skin Devices as Skin Replacements: Insights into Superficial Treatment Low, Zhi Wei Kenny; Li, Zibiao; Owh, Cally Small, Vol. 15, Issue 9 https://doi.org/10.1002/smll.201805453	journal	January 2019
State-of-the-art MEMS and microsystem tools for brain research Seymour, John P.; Wu, Fan; Wise, Kensall D. Microsystems & Nanoengineering, Vol. 3, Issue 1 https://doi.org/10.1038/micronano.2016.66	journal	January 2017
Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice Sidor, M. M.; Spencer, S. M.; Dzirasa, K. Molecular Psychiatry, Vol. 20, Issue 11 https://doi.org/10.1038/mp.2014.167	journal	January 2015
Materials and technologies for soft implantable neuroprostheses Lacour, Stéphanie P.; Courtine, Grégoire; Guck, Jochen Nature Reviews Materials, Vol. 1, Issue 10 https://doi.org/10.1038/natrevmats.2016.63	journal	September 2016
Tissue–electronics interfaces: from implantable devices to engineered tissues Feiner, Ron; Dvir, Tal Nature Reviews Materials, Vol. 3, Issue 1 https://doi.org/10.1038/natrevmats.2017.76	journal	November 2017
Switchable photooxygenation catalysts that sense higher-order amyloid structures Taniguchi, Atsuhiko; Shimizu, Yusuke; Oisaki, Kounosuke Nature Chemistry, Vol. 8, Issue 10 https://doi.org/10.1038/nchem.2550	journal	June 2016
Optical control of insulin release using a photoswitchable sulfonylurea Broichhagen, Johannes; Schönberger, Matthias; Cork, Simon C. Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms6116	journal	October 2014
Transparent and flexible low noise graphene electrodes for simultaneous electrophysiology and neuroimaging Kuzum, Duygu; Takano, Hajime; Shim, Euijae Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms6259	journal	October 2014
Beyond the hammer and the scalpel: selective circuit control for the epilepsies Krook-Magnuson, Esther; Soltesz, Ivan Nature Neuroscience, Vol. 18, Issue 3 https://doi.org/10.1038/nn.3943	journal	February 2015
A transparent bending-insensitive pressure sensor Lee, Sungwon; Reuveny, Amir; Reeder, Jonathan Nature Nanotechnology, Vol. 11, Issue 5 https://doi.org/10.1038/nnano.2015.324	journal	January 2016
Utilizing the power of Cerenkov light with nanotechnology Shaffer, Travis M.; Pratt, Edwin C.; Grimm, Jan Nature Nanotechnology, Vol. 12, Issue 2 https://doi.org/10.1038/nnano.2016.301	journal	February 2017
Locus Coeruleus Kappa-Opioid Receptors Modulate Reinstatement of Cocaine Place Preference Through a Noradrenergic Mechanism Al-Hasani, Ream; McCall, Jordan G.; Foshage, Audra M. Neuropsychopharmacology, Vol. 38, Issue 12 https://doi.org/10.1038/npp.2013.151	journal	June 2013
Architectural Representation of Valence in the Limbic System Namburi, Praneeth; Al-Hasani, Ream; Calhoon, Gwendolyn G. Neuropsychopharmacology, Vol. 41, Issue 7 https://doi.org/10.1038/npp.2015.358	journal	December 2015
Preparation and implementation of optofluidic neural probes for in vivo wireless pharmacology and optogenetics McCall, Jordan G.; Qazi, Raza; Shin, Gunchul Nature Protocols, Vol. 12, Issue 2 https://doi.org/10.1038/nprot.2016.155	journal	January 2017
Inductively coupled, mm-sized, single channel optical neuro-stimulator with intensity enhancer Khan, Wasif; Jia, Yaoyao; Madi, Fatma Microsystems & Nanoengineering, Vol. 5, Issue 1 https://doi.org/10.1038/s41378-019-0061-6	journal	June 2019
Inorganic semiconducting materials for flexible and stretchable electronics Yu, Ki Jun; Yan, Zheng; Han, Mengdi npj Flexible Electronics, Vol. 1, Issue 1 https://doi.org/10.1038/s41528-017-0003-z	journal	September 2017
Glial responses to implanted electrodes in the brain Salatino, Joseph W.; Ludwig, Kip A.; Kozai, Takashi D. Y. Nature Biomedical Engineering, Vol. 1, Issue 11 https://doi.org/10.1038/s41551-017-0154-1	journal	November 2017
Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy Yamagishi, Kento; Kirino, Izumi; Takahashi, Isao Nature Biomedical Engineering, Vol. 3, Issue 1 https://doi.org/10.1038/s41551-018-0261-7	journal	July 2018
Morphable 3D mesostructures and microelectronic devices by multistable buckling mechanics Fu, Haoran; Nan, Kewang; Bai, Wubin Nature Materials, Vol. 17, Issue 3 https://doi.org/10.1038/s41563-017-0011-3	journal	January 2018
Continuous-wave upconverting nanoparticle microlasers Fernandez-Bravo, Angel; Yao, Kaiyuan; Barnard, Edward S. Nature Nanotechnology, Vol. 13, Issue 7 https://doi.org/10.1038/s41565-018-0161-8	journal	June 2018
Novel electrode technologies for neural recordings Hong, Guosong; Lieber, Charles M. Nature Reviews Neuroscience, Vol. 20, Issue 6 https://doi.org/10.1038/s41583-019-0140-6	journal	March 2019
An integrated multi-electrode-optrode array for in vitro optogenetics Welkenhuysen, Marleen; Hoffman, Luis; Luo, Zhengxiang Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep20353	journal	February 2016
“Optical communication with brain cells by means of an implanted duplex micro-device with optogenetics and Ca2+ fluoroimaging” Kobayashi, Takuma; Haruta, Makito; Sasagawa, Kiyotaka Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep21247	journal	February 2016
High-performance transparent pressure sensors based on sea-urchin shaped metal nanoparticles and polyurethane microdome arrays for real-time monitoring Lee, Donghwa; Kim, Jongyoun; Kim, Honggi Nanoscale, Vol. 10, Issue 39 https://doi.org/10.1039/c8nr05843a	journal	January 2018
Recent innovations in artificial skin Low, Zhi Wei Kenny; Li, Zibiao; Owh, Cally Biomaterials Science, Vol. 8, Issue 3 https://doi.org/10.1039/c9bm01445d	journal	January 2020
Optogenetic neurostimulation of auricular vagus using flexible OLED display technology to treat chronic inflammatory disease and mental health disorders Smith, J.; Shah, A.; Lee, Y. K. Electronics Letters, Vol. 52, Issue 11 https://doi.org/10.1049/el.2015.3450	journal	May 2016
Growth and characterizations of GaN micro-rods on graphene films for flexible light emitting diodes Chung, Kunook; Beak, Hyeonjun; Tchoe, Youngbin APL Materials, Vol. 2, Issue 9 https://doi.org/10.1063/1.4894780	journal	September 2014
1 mm ³ -sized optical neural stimulator based on CMOS integrated photovoltaic power receiver Tokuda, Takashi; Ishizu, Takaaki; Nattakarn, Wuthibenjaphonchai AIP Advances, Vol. 8, Issue 4 https://doi.org/10.1063/1.5024243	journal	April 2018
Beyond solid-state lighting: Miniaturization, hybrid integration, and applications of GaN nano- and micro-LEDs Wasisto, Hutomo Suryo; Prades, Joan Daniel; Gülink, Jan Applied Physics Reviews, Vol. 6, Issue 4 https://doi.org/10.1063/1.5096322	journal	December 2019
Syringe-injectable mesh electronics integrate seamlessly with minimal chronic immune response in the brain Zhou, Tao; Hong, Guosong; Fu, Tian-Ming Proceedings of the National Academy of Sciences, Vol. 114, Issue 23 https://doi.org/10.1073/pnas.1705509114	journal	May 2017
In vivo wireless photonic photodynamic therapy Bansal, Akshaya; Yang, Fengyuan; Xi, Tian Proceedings of the National Academy of Sciences, Vol. 115, Issue 7 https://doi.org/10.1073/pnas.1717552115	journal	January 2018
Wireless optoelectronic photometers for monitoring neuronal dynamics in the deep brain Lu, Luyao; Gutruf, Philipp; Xia, Li Proceedings of the National Academy of Sciences, Vol. 115, Issue 7 https://doi.org/10.1073/pnas.1718721115	journal	January 2018
Chronic and acute stress monitoring by electrophysiological signals from adrenal gland Sunwoo, Sung Hyuk; Lee, Ju Seung; Bae, SungJun Proceedings of the National Academy of Sciences, Vol. 116, Issue 4 https://doi.org/10.1073/pnas.1806392115	journal	January 2019
GaN-based micro-LED arrays on flexible substrates for optical cochlear implants Goßler, Christian; Bierbrauer, Colin; Moser, Rüdiger Journal of Physics D: Applied Physics, Vol. 47, Issue 20 https://doi.org/10.1088/0022-3727/47/20/205401	journal	April 2014
Structural control of InP/ZnS core/shell quantum dots enables high-quality white LEDs Kumar, Baskaran Ganesh; Sadeghi, Sadra; Melikov, Rustamzhon Nanotechnology, Vol. 29, Issue 34 https://doi.org/10.1088/1361-6528/aac8c9	journal	June 2018
Design and manufacturing challenges of optogenetic neural interfaces: a review Goncalves, S. B.; Ribeiro, J. F.; Silva, A. F. Journal of Neural Engineering, Vol. 14, Issue 4 https://doi.org/10.1088/1741-2552/aa7004	journal	May 2017
A nanofabricated optoelectronic probe for manipulating and recording neural dynamics Li, Bingzhao; Lee, Kwang; Masmanidis, Sotiris C. Journal of Neural Engineering, Vol. 15, Issue 4 https://doi.org/10.1088/1741-2552/aabc94	journal	May 2018
Colour optimization of phosphor-converted flexible nitride nanowire white light emitting diodes Guan, Nan; Amador-Mendez, Nuño; Wang, Junkang Journal of Physics: Photonics, Vol. 1, Issue 3 https://doi.org/10.1088/2515-7647/ab2c84	journal	July 2019
A widely adaptable analytical method for thermal analysis of flexible electronics with complex heat source structures Yin, Yafei; Li, Min; Yuan, Wei Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 475, Issue 2228 https://doi.org/10.1098/rspa.2019.0402	journal	August 2019
Remote control of neural function by X-ray-induced scintillation Matsubara, Takanori; Yanagida, Takayuki; Kawaguchi, Noriaki Nature Communications https://doi.org/10.1101/798702	journal	November 2020
Defining the ionic mechanisms of optogenetic control of vascular tone by channelrhodopsin-2: Channelrhodopsin-2 in vascular optogenetics Rorsman, Nils J. G.; Ta, Chau M.; Garnett, Hannah British Journal of Pharmacology, Vol. 175, Issue 11 https://doi.org/10.1111/bph.14183	journal	April 2018
Patterned photostimulation via visible-wavelength photonic probes for deep brain optogenetics Segev, Eran; Reimer, Jacob; Moreaux, Laurent C. Neurophotonics, Vol. 4, Issue 1 https://doi.org/10.1117/1.nph.4.1.011002	journal	December 2016
The Opioid Crisis and the Future of Addiction and Pain Therapeutics Coussens, Nathan P.; Sittampalam, G. Sitta; Jonson, Samantha G. Journal of Pharmacology and Experimental Therapeutics, Vol. 371, Issue 2 https://doi.org/10.1124/jpet.119.259408	journal	September 2019
Elastocapillary self-assembled neurotassels for stable neural activity recordings Guan, S.; Wang, J.; Gu, X. Science Advances, Vol. 5, Issue 3 https://doi.org/10.1126/sciadv.aav2842	journal	March 2019
Beyond the brain: Optogenetic control in the spinal cord and peripheral nervous system Montgomery, Kate L.; Iyer, Shrivats M.; Christensen, Amelia J. Science Translational Medicine, Vol. 8, Issue 337 https://doi.org/10.1126/scitranslmed.aad7577	journal	May 2016
A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat Koh, A.; Kang, D.; Xue, Y. Science Translational Medicine, Vol. 8, Issue 366 https://doi.org/10.1126/scitranslmed.aaf2593	journal	November 2016
Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations Bruegmann, Tobias; Boyle, Patrick M.; Vogt, Christoph C. Journal of Clinical Investigation, Vol. 126, Issue 10 https://doi.org/10.1172/jci88950	journal	September 2016
Twitches, Blinks, and Fidgets: Important Generators of Ongoing Neural Activity Drew, Patrick J.; Winder, Aaron T.; Zhang, Qingguang The Neuroscientist, Vol. 25, Issue 4 https://doi.org/10.1177/1073858418805427	journal	October 2018
RF power harvesting: a review on designing methodologies and applications Tran, Le-Giang; Cha, Hyouk-Kyu; Park, Woo-Tae Micro and Nano Systems Letters, Vol. 5, Issue 1 https://doi.org/10.1186/s40486-017-0051-0	journal	February 2017
Hybrid integration of an evanescently coupled AlGaAs microdisk resonator with a silicon waveguide by nanoscale-accuracy transfer printing Guilhabert, B.; McPhillimy, J.; May, S. Optics Letters, Vol. 43, Issue 20 https://doi.org/10.1364/ol.43.004883	journal	January 2018
Micro-Reflector Integrated Multichannel μLED Optogenetic Neurostimulator With Enhanced Intensity Khan, Wasif; Setien, Monica; Purcell, Erin Frontiers in Mechanical Engineering, Vol. 4 https://doi.org/10.3389/fmech.2018.00017	journal	November 2018
Light-Controlled Mammalian Cells and Their Therapeutic Applications in Synthetic Biology Maysam, Mansouri,; Tobias, Strittmatter,; Martin, Fussenegger, ETH Zurich https://doi.org/10.3929/ethz-b-000317085	text	January 2019
Exploration of Micro-VCSEL Ultra-low Biasing Scheme for Pulse Generation Wang, Tao; Wang, Gaofeng; Puccioni, Gian Piero arXiv https://doi.org/10.48550/arxiv.1811.04571	text	January 2018

Similar Records

Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics

Journal Article · Wed Nov 06 19:00:00 EST 2013 · Nature Protocols · OSTI ID:1875435

Wireless Optogenetic Modulation of Cortical Neurons Enabled by Radioluminescent Nanoparticles

Journal Article · Tue Feb 23 19:00:00 EST 2021 · ACS Nano · OSTI ID:1774566

Related Subjects

42 ENGINEERING

Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics

Citation Formats

References (48)

Cited By (111)

Similar Records

Related Subjects