Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics

Kim, Tae-il; McCall, Jordan G.; Jung, Yei Hwan; Huang, Xian; Siuda, Edward R.; Li, Yuhang; Song, Jizhou; Song, Young Min; Pao, Hsuan An; Kim, Rak-Hwan; Lu, Chaofeng; Lee, Sung Dan; Song, Il-Sun; Shin, GunChul; Al-Hasani, Ream; Kim, Stanley; Tan, Meng Peun; Huang, Yonggang; Omenetto, Fiorenzo G.; Rogers, John A.; Bruchas, Michael R.

doi:10.1126/science.1232437

Title: Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics

Journal Article · Fri Apr 12 00:00:00 EDT 2013 · Science

DOI:https://doi.org/10.1126/science.1232437· OSTI ID:1875506

Kim, Tae-il ^[1]; McCall, Jordan G. ^[2]; Jung, Yei Hwan ^[3]; Huang, Xian ^[4]; Siuda, Edward R. ^[2]; Li, Yuhang ^[5]; Song, Jizhou ^[6]; Song, Young Min ^[4]; Pao, Hsuan An ^[4]; Kim, Rak-Hwan ^[4]; Lu, Chaofeng ^[7]; Lee, Sung Dan ^[4]; Song, Il-Sun ^[4]; Shin, GunChul ^[4]; Al-Hasani, Ream ^[2]; Kim, Stanley ^[4]; Tan, Meng Peun ^[4]; Huang, Yonggang ^[5]; Omenetto, Fiorenzo G. ^[8]; Rogers, John A. ^[4] more »

Univ. of Illinois at Urbana-Champaign, IL (United States); Sungkyunkwan University (SKKU), Suwon (Korea)
Washington Univ. School of Medicine, St. Louis, MO (United States)
Univ. of Illinois at Urbana-Champaign, IL (United States); Univ. of Wisconsin, Madison, WI (United States)
Univ. of Illinois at Urbana-Champaign, IL (United States)
Northwestern Univ., Evanston, IL (United States)
Univ. of Miami, Coral Gables, FL (United States)
Zhejiang Univ., Hangzhou (China)
Tufts Univ., Medford, MA (United States)

Successful integration of advanced semiconductor devices with biological systems will accelerate basic scientific discoveries and their translation into clinical technologies. In neuroscience generally, and in optogenetics in particular, the ability to insert light sources, detectors, sensors, and other components into precise locations of the deep brain yields versatile and important capabilities. Here, we introduce an injectable class of cellular-scale optoelectronics that offers such features, with examples of unmatched operational modes in optogenetics, including completely wireless and programmed complex behavioral control over freely moving animals. Furthermore, the ability of these ultrathin, mechanically compliant, biocompatible devices to afford minimally invasive operation in the soft tissues of the mammalian brain foreshadow applications in other organ systems, with potential for broad utility in biomedical science and engineering.

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Research Organization:: Univ. of Illinois at Urbana-Champaign, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division; NIH Common Fund; National Institute of Neurological Disorders and Stroke; National Institutes of Health (NIH); National Institute on Drug Abuse

Grant/Contract Number:: FG02-07ER46471

OSTI ID:: 1875506

Journal Information:: Science, Vol. 340, Issue 6129; ISSN 0036-8075

Publisher:: AAASCopyright Statement

Country of Publication:: United States

Language:: English

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