Wireless Optogenetic Modulation of Cortical Neurons Enabled by Radioluminescent Nanoparticles

Chen, Zhaowei; Tsytsarev, Vassiliy; Finfrock, Y. Zou; Antipova, Olga A.; Cai, Zhonghou; Arakawa, Hiroyuki; Lischka, Fritz W.; Hooks, Bryan M.; Wilton, Rosemarie; Wang, Dongyi; Liu, Yi; Gaitan, Brandon; Tao, Yang; Chen, Yu; Erzurumlu, Reha S.; Yang, Huanghao; Rozhkova, Elena A.

doi:10.1021/acsnano.0c10436

Wireless Optogenetic Modulation of Cortical Neurons Enabled by Radioluminescent Nanoparticles

Journal Article · Wed Feb 24 00:00:00 EST 2021 · ACS Nano

DOI:https://doi.org/10.1021/acsnano.0c10436· OSTI ID:1774566

^[1]; Tsytsarev, Vassiliy ^[2]; Finfrock, Y. Zou ^[3]; ^[4]; Cai, Zhonghou ^[4]; Arakawa, Hiroyuki ^[5]; Lischka, Fritz W. ^[6]; Hooks, Bryan M. ^[7]; Wilton, Rosemarie ^[4]; Wang, Dongyi ^[2]; Liu, Yi ^[2]; Gaitan, Brandon ^[2]; Tao, Yang ^[2]; Chen, Yu ^[2]; Erzurumlu, Reha S. ^[5]; ^[8]; ^[4]

Argonne National Lab. (ANL), Argonne, IL (United States); Fuzhou University (China)
University of Maryland, College Park, MD (United States)
Argonne National Lab. (ANL), Argonne, IL (United States); Canadian Light Source Inc., Saskatoon, SK (Canada)
Argonne National Lab. (ANL), Argonne, IL (United States)
University of Maryland School of Medicine, Baltimore, MD (United States)
Uniformed Services University of the Health Sciences, Bethesda, MD (United States)
University of Pittsburgh, PA (United States)
Fuzhou University (China)

While offering high precision control of neural circuits, optogenetics is hampered by the necessity to implant fiber-optic waveguides in order to deliver photons to genetically engineered light-gated neurons in the brain. Unlike laser light, X-rays freely pass biological barriers. In this work, we show that radioluminescent Gd₂(WO₄)₃:Eu nanoparticles, which absorb an external X-rays energy and then down-converter it into optical photons with wavelengths of ~610 nm, can be used for the transcranial stimulation of cortical neurons expressing red-shifted, ~590-630 nm, channelrhodopsin ReaChR, thereby promoting optogenetic neural control to the practical implementation of minimally-invasive wireless deep brain stimulation.

View Accepted Manuscript (DOE)

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: National Institutes of Health (NIH); National Science Foundation (NSF); USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities Division

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1774566

Journal Information:: ACS Nano, Journal Name: ACS Nano Journal Issue: 3 Vol. 15; ISSN 1936-0851

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Wireless Optogenetic Modulation of Cortical Neurons Enabled by Radioluminescent Nanoparticles

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