Effects of ionizing radiations on enzymes: The influence of gamma and x-irradiation on phosphatases and aerobic phosphorylation

Technical Report · Sun Dec 31 00:00:00 EST 1950

DOI:https://doi.org/10.2172/182178· OSTI ID:182178

DuBois, K. P.; Mazur, M.; Cochran, K. W.

In recent studies on the effects of ionizing radiations on enzymatic reactions we observed that the rate of hydrolysis of certain phosphate esters by alkaline phosphates was increased after exposure of mice to lethal doses of gamma radiation and X-rays. In our experiments no change in the adenosine triphosphatase activity of several tissues was noted after irradiation but the hydrolysis of {beta}-glycerophosphate and 5-adenylic acid was significantly increased in some tissues. To obtain further information on the nature and extent of the increase in phosphatase activity of tissues after irradiation we have continued investigations on alkaline phosphatases. 13 refs., 1 fig., 7 tabs.

• Research Organization: Chicago Univ., IL (United States)
• OSTI ID: 182178
• Report Number(s): COO-22; ON: TI95013638; TRN: 96:000933-0002
• Resource Relation: Other Information: PBD: [1950]; Related Information: Is Part Of University of Chicago Toxicity Laboratory quarterly progress report No. 7; PB: 105 p.
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
55 BIOLOGY AND MEDICINE
BASIC STUDIES
MICE
BIOLOGICAL RADIATION EFFECTS
ALKALINE PHOSPHATASE
ENZYME ACTIVITY
ESTERS
HYDROLYSIS
NUCLEOTIDASES
BIOLOGICAL EFFECTS
ADENYLIC ACID
IONIZING RADIATIONS
ENZYMES
X RADIATION
PHOSPHORYLATION
TANTALUM 182
CITRATES
FLUORIDES