Endrin-induced toxicity in normal and irradiated rats
Journal Article
·
· Environ. Res.; (United States)
In this investigation, enzymatic changes were investigated after a single dose of endrin (10 mg/kg) administered to normal and irradiated rats (900 rads). In both normal and irradiated rats, endrin caused a significant increase in serum GOT and GPT, and adenosine triphosphatase; acid and alkaline phosphatase, succinic dehydrogenase and glucose-6-phosphatase decreased significantly during varying periods of 2 to 48 hr after treatment. In irradiated rats given endrin, the changes appeared earlier and were more pronounced than in normal rats and in rats given endrin alone. This study reveals that endrin, like other toxic agents, leads to tissue injury and has effects on aerobic and anaerobic metabolism of glucose in liver and kidney tissues, as evidenced by changes in various enzymes. Endrin also appears to enhance the effect of radiation, except in the case of adenosine triphosphatase, where endurin neutralizes the effect of radiation on the mitochondrial membrane.
- Research Organization:
- Punjab Univ., Chandigarh, India
- OSTI ID:
- 6592291
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 16; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560114* -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID PHOSPHATASE
AEROBIC CONDITIONS
ALDEHYDES
ALKALINE PHOSPHATASE
ANAEROBIC CONDITIONS
ANIMALS
ATP-ASE
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD SERUM
BODY
CARBOHYDRATES
CELL CONSTITUENTS
DEHYDROGENASES
DIGESTIVE SYSTEM
ENZYMES
ESTERASES
GLANDS
GLUCOSE
HEXOSES
HYDROLASES
IRRADIATION
KIDNEYS
LIVER
MAMMALS
METABOLISM
MITOCHONDRIA
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
OXIDOREDUCTASES
PESTICIDES
PHOSPHATASES
RADIATION EFFECTS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SACCHARIDES
TOXICITY
VERTEBRATES
560152 -- Radiation Effects on Animals-- Animals
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID PHOSPHATASE
AEROBIC CONDITIONS
ALDEHYDES
ALKALINE PHOSPHATASE
ANAEROBIC CONDITIONS
ANIMALS
ATP-ASE
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD SERUM
BODY
CARBOHYDRATES
CELL CONSTITUENTS
DEHYDROGENASES
DIGESTIVE SYSTEM
ENZYMES
ESTERASES
GLANDS
GLUCOSE
HEXOSES
HYDROLASES
IRRADIATION
KIDNEYS
LIVER
MAMMALS
METABOLISM
MITOCHONDRIA
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
OXIDOREDUCTASES
PESTICIDES
PHOSPHATASES
RADIATION EFFECTS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SACCHARIDES
TOXICITY
VERTEBRATES