No-carrier-added (18F)-N-methylspiroperidol

Patent · Tue Jul 06 00:00:00 EDT 1993

OSTI ID:1176656

Shiue, Chyng-Yann; Fowler, Joanna S.; Wolf, Alfred P.

There is disclosed a radioligand labeled with a positron emitting radionuclide suitable for dynamic study in living humans with positron emission transaxial tomography. [¹⁸F]-N-methylspiroperidol, exhibiting extremely high affinity for the dopamine receptors, provides enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to provide [¹⁸F]-N-methylspiroperidol as a radioligand superior to known radioligands for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for this material is disclosed.

• Research Organization: Brookhaven National Laboratory (BNL), Upton, NY (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC02-76CH00016
• Assignee: The United States of America as represented by the United States Department of Energy (Washington, DC)
• Patent Number(s): H001209
• Application Number: 06/784149
• OSTI ID: 1176656
• Resource Relation: Patent File Date: 1985 Oct 04
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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