No-carrier-added (18F)-N-methylspiroperidol
Patent
·
OSTI ID:875158
- East Setauket, NY
- Bellport, NY
- Setauket, NY
There is disclosed a radioligand labeled with a positron emitting radionuclide suitable for dynamic study in living humans with positron emission transaxial tomography. [.sup.18 F]-N-methylspiroperidol, exhibiting extremely high affinity for the dopamine receptors, provides enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to provide [.sup.18 F]-N-methylspiroperidol as a radioligand superior to known radioligands for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for this material is disclosed.
- Research Organization:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC02-76CH00016
- Assignee:
- United States of America as represented by United States (Washington, DC)
- Patent Number(s):
- H001209
- Application Number:
- 06/784149
- OSTI ID:
- 875158
- Country of Publication:
- United States
- Language:
- English
Imaging dopamine receptors in the human brain by positron tomography
|
journal | September 1983 |
Preliminary studies with [18F]haloperidol: a radioligand for in vivo studies of the dopamine receptors
|
journal | June 1980 |
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combine
concomitant
disclosed
disease
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emission
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emitting
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living
living human
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positron
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radionuclide
receptors
reduced
retention
statutory invention registration
study
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transaxial
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uptake