No-carrier-added [.sup.18 F]-N-fluoroalkylspiroperidols

Patent · Sat Dec 31 23:00:00 EST 1988

OSTI ID:867124

Shiue, Chyng-Yann ^[1]; Wolf, Alfred P ^[2]; Bai, Lan-Qin ^[3]; Teng, Ren-Tui ^[3]

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1. East Setauket, NY
2. Setauket, NY
3. Upton, NY

There is disclosed radioligands labeled with the position emitting radionuclide [.sup.18 F] suitable for dynamic study in living humans with position emission transaxial tomography. These new [.sup.18 F]-N-fluoroalkylspiroperidols, wherein the alkyl group contains from 2-6 carbon atoms, exhibit extremely high affinity for the dopamine receptors and provide enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to make these new radioligands useful for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for these radioligands as well as a new procedure for preparing the radiolabeled alkyl halide alkylating reagents are also disclosed.

• Research Organization: ASSOC UNIVERSITIES INC
• DOE Contract Number: AC02-76CH00016
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 4871527
• OSTI ID: 867124
• Country of Publication: United States
• Language: English

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