Method of tissue repair using a composite material

Hutchens, Stacy A; Woodward, Jonathan; Evans, Barbara R; O'Neill, Hugh M

Title: Method of tissue repair using a composite material

Patent · Tue Mar 18 00:00:00 EDT 2014

OSTI ID:1127166

Hutchens, Stacy A; Woodward, Jonathan; Evans, Barbara R; O'Neill, Hugh M

A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-000R22725

Assignee:: UT-Battelle, LLC (Oak Ridge, TN); University of Tennessee Research Foundation (Knoxville, TN)

Patent Number(s):: 8,673,337

Application Number:: 13/340,114

OSTI ID:: 1127166

Country of Publication:: United States

Language:: English

References (34)

Process for producing inorganic biomaterial Kasuga, Toshihiro; Nakajima, Kiichi https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5232878 US Patent Document 5,232,878	patent	August 1993
Polymeric-hydroxyapatite bone composite Laurencin, Cato T.; Devin, Jessica; Attawia, Muhammed https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5626861 US Patent Document 5,626,861	patent	May 1997
Calcium phosphate compound-cellulose fiber composite material and method for production thereof Mucalo, Michael Roger; Yokogawa, Yoshiyuki; Toriyama, Motohiro https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5698265 US Patent Document 5,698,265	patent	December 1997
Calcium phosphate cements comprising amorophous calcium phosphate Constantz, Brent R.; Barr, Bryan M. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5782971 US Patent Document 5,782,971	patent	July 1998
Inorganic porous crystals-hydrophilic macromolecule composite Sugiyama, Kouju https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5981052 US Patent Document 5,981,052	patent	November 1999
Low density body Suenaga, Hiroshi; Yoshimura, Yukihiro; Ishikawa, Hisao https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6133170 US Patent Document 6,133,170	patent	October 2000
Bone substitute composition comprising hydroxyapatite and a method of production therefor Brown, Paul; Huisen, Kevor S. Ten; Martin, Roger Isaac https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6201039 US Patent Document 6,201,039	patent	March 2001
Mineralized collagen membrane and method of making same Liu, Sung-Tsuen https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6300315 US Patent Document 6,300,315	patent	October 2001
Bioresorbable ceramic composites Lee, Dosuk D.; Rey, Christian; Aiolova, Maria https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6331312 US Patent Document 6,331,312	patent	December 2001
Composition containing inorganic porous crystals-hydrophilic macromolecule composite and product made therefrom Sugiyama, Kouju; Nakano, Maki; Utsunomiya, Takaaki https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6372333 US Patent Document 6,372,333	patent	April 2002
Polymeric composite material and method of manufacturing the same Uryu, Masaru; Tokura, Kunihiko https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6410618 US Patent Document 6,410,618	patent	June 2002
Porous tissue scaffoldings for the repair or regeneration of tissue Vyakarnam, Murty; Zimmerman, Mark C.; Scopelianos, Angelo https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6534084 US Patent Document 6,534,084	patent	March 2003
Composition and process for bone growth and repair Thorne, Kevin J.; Benedict, James J. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20020114795 US Patent Application 09/746921; 20020114795	patent-application	August 2002
Method and apparatus for engineered regenrative biostructures such as hydroxyapatite substrates for bone healing applications Beam, Heather Ann; Bradbury, Thomas J.; Chesmel, Kathleen D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030065400 US Patent Application 10/122129; 20030065400	patent-application	April 2003
Fiber-reinforced, porous, biodegradable implant device Slivka, Michael A.; Niederauer, Gabriele G.; Kieswetter, Kristine https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050240281 US Patent Application 10/931474; 20050240281	patent-application	October 2005
Inclusion of solid particles in bacterial cellulose G., Serafica; R., Mormino; H., Bungay Applied Microbiology and Biotechnology, Vol. 58, Issue 6 https://doi.org/10.1007/s00253-002-0978-8	journal	May 2002
In vitro evaluation of a new injectable calcium phosphate material Grimandi, G.; Weiss, P.; Millot, F. Journal of Biomedical Materials Research, Vol. 39, Issue 4, p. 660-666 https://doi.org/10.1002/(SICI)1097-4636(19980315)39:4<660::AID-JBM22>3.0.CO;2-9	journal	March 1998
The structure and mechanical properties of sheets prepared from bacterial cellulose Yamanaka, S.; Watanabe, K.; Kitamura, N. Journal of Materials Science, Vol. 24, Issue 9 https://doi.org/10.1007/BF01139032	journal	September 1989
The Phylogeny of Acetic Acid Bacteria Based on the Partial Sequences of 16S Ribosomal RNA: The Elevation of the Subgenus Gluconoacetobacter to the Generic Level Yamada, Yuzo; Hoshino, Ken-ichiro; Ishikawa, Tetsuya Bioscience, Biotechnology, and Biochemistry, Vol. 61, Issue 8 https://doi.org/10.1271/bbb.61.1244	journal	January 1997
Biocompatibility of Cellulose Sponge with Bone Märtson, M.; Viljanto, J.; Hurme, T. European Surgical Research, Vol. 30, Issue 6 https://doi.org/10.1159/000008609	journal	January 1998
Injectable gels for tissue engineering Gutowska, Anna; Jeong, Byeongmoon; Jasionowski, Marek The Anatomical Record, Vol. 263, Issue 4, p. 342-349 https://doi.org/10.1002/ar.1115	journal	January 2001
Biomaterial developments for bone tissue engineering Burg, Karen J. L.; Porter, Scott; Kellam, James F. Biomaterials, Vol. 21, Issue 23, p. 2347-2359 https://doi.org/10.1016/S0142-9612(00)00102-2	journal	December 2000
Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function Ducheyne, P. Biomaterials, Vol. 20, Issue 23-24 https://doi.org/10.1016/S0142-9612(99)00181-7	journal	December 1999
Cellulose phosphates as biomaterials. In vivo biocompatibility studies Fricain, J. C.; Granja, P. L.; Barbosa, M. A. Biomaterials, Vol. 23, Issue 4 https://doi.org/10.1016/S0142-9612(01)00152-1	journal	February 2002
Acetobacter cellulose pellicle as a temporary skin substitute Fontana, J. D.; De Souza, A. M.; Fontana, C. K. Applied Biochemistry and Biotechnology, Vol. 24-25, Issue 1 https://doi.org/10.1007/BF02920250	journal	March 1990
Bacterial synthesized cellulose — artificial blood vessels for microsurgery Klemm, Dieter; Schumann, Dieter; Udhardt, Ulrike Progress in Polymer Science, Vol. 26, Issue 9, p. 1561-1603 https://doi.org/10.1016/S0079-6700(01)00021-1	journal	November 2001
Is cellulose sponge degradable or stable as implantation material? An in vivo subcutaneous study in the rat Märtson, Matis; Viljanto, Jouko; Hurme, Timo Biomaterials, Vol. 20, Issue 21, p. 1989-1995 https://doi.org/10.1016/S0142-9612(99)00094-0	journal	November 1999
Duraplasty with biosynthetic cellulose: an experimental study Mello, Luis Renato; Feltrin, Leonir T.; Fontes Neto, Paulo T. Journal of Neurosurgery, Vol. 86, Issue 1 https://doi.org/10.3171/jns.1997.86.1.0143	journal	January 1997
Tissue biocompatibility of cellulose and its derivatives Miyamoto, Takeaki; Takahashi, Shin-ichi; Ito, Hiraku Journal of Biomedical Materials Research, Vol. 23, Issue 1 https://doi.org/10.1002/jbm.820230110	journal	January 1989
Synthesis and thermal behavior of well-crystallized calcium-deficient phosphate apatite Mortier, Anne; Lemaitre, Jacques; Rodrique, Luc Journal of Solid State Chemistry, Vol. 78, Issue 2, p. 215-219 https://doi.org/10.1016/0022-4596(89)90099-6	journal	February 1989
Factors affecting Production of Cellulose at the Air/ Liquid Interface of a Culture of Acetobacter xylinum Schramm, M.; Hestrin, S. Journal of General Microbiology, Vol. 11, Issue 1 https://doi.org/10.1099/00221287-11-1-123	journal	August 1954
Synthesis of biomimetic Ca-hydroxyapatite powders at 37°C in synthetic body fluids Cüneyt Tas, A. Biomaterials, Vol. 21, Issue 14 https://doi.org/10.1016/S0142-9612(00)00019-3	journal	July 2000
Porous calcium phosphate coating over phosphorylated chitosan film by a biomimetic method Varma, H. Biomaterials, Vol. 20, Issue 9 https://doi.org/10.1016/S0142-9612(98)00243-9	journal	May 1999
Calcium-deficient apatite: A firstin vivo study concerning bone ingrowth Bourgeois, B.; Laboux, O.; Obadia, L. Journal of Biomedical Materials Research, Vol. 65A, Issue 3 https://doi.org/10.1002/jbm.a.10518	journal	May 2003

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