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Title: Method of tissue repair using a composite material

Patent ·
OSTI ID:1241102

A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-00OR22725
Assignee:
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (Knoxville, TN)
Patent Number(s):
9,272,045
Application Number:
14/200,060
OSTI ID:
1241102
Resource Relation:
Patent File Date: 2014 Mar 07
Country of Publication:
United States
Language:
English

References (38)

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